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Neurological Soft Signs Are Associated With Altered White Matter in Patients With Schizophrenia
Schizophrenia Bulletin ( IF 6.6 ) Pub Date : 2021-07-16 , DOI: 10.1093/schbul/sbab089
Petra Verena Viher 1 , Katharina Stegmayer 1 , Tobias Bracht 1 , Andrea Federspiel 1 , Stephan Bohlhalter 2, 3 , Werner Strik 1 , Roland Wiest 4 , Sebastian Walther 1
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Neurological soft signs (NSS) are related to grey matter and functional brain abnormalities in schizophrenia. Studies in healthy subjects suggest, that NSS are also linked to white matter. However, the association between NSS and white matter abnormalities in schizophrenia remains to be elucidated. The present study investigated, if NSS are related to white matter alterations in patients with schizophrenia. The total sample included 42 healthy controls and 41 patients with schizophrenia. We used the Neurological Evaluation Scale (NES), and we acquired diffusion weighted magnetic resonance imaging to assess white matter on a voxel-wise between subject statistic. In patients with schizophrenia, linear associations between NES with fractional anisotropy (FA), radial, axial, and mean diffusivity were analyzed with tract-based spatial statistics while controlling for age, medication dose, the severity of the disease, and motion. The main pattern of results in patients showed a positive association of NES with all diffusion measures except FA in important motor pathways: the corticospinal tract, internal capsule, superior longitudinal fascicle, thalamocortical radiations and corpus callosum. In addition, exploratory tractography analysis revealed an association of the right aslant with NES in patients. These results suggest that specific white matter alterations, that is, increased diffusivity might contribute to NSS in patients with schizophrenia.

中文翻译:

精神分裂症患者的神经软体征与白质改变有关

神经软体征 (NSS) 与精神分裂症患者的灰质和脑功能异常有关。对健康受试者的研究表明,NSS 也与白质有关。然而,NSS 与精神分裂症白质异常之间的关联仍有待阐明。本研究调查了 NSS 是否与精神分裂症患者的白质改变有关。总样本包括 42 名健康对照和 41 名精神分裂症患者。我们使用了神经学评估量表 (NES),并获得了弥散加权磁共振成像来评估受试者统计数据之间体素方面的白质。在精神分裂症患者中,NES 与分数各向异性 (FA)、径向、轴向、在控制年龄、药物剂量、疾病严重程度和运动的同时,使用基于束的空间统计数据分析平均扩散率。患者的主要结果显示 NES 与除 FA 在重要运动通路中的所有扩散测量呈正相关:皮质脊髓束、内囊、上纵束、丘脑皮质辐射和胼胝体。此外,探索性纤维束成像分析揭示了患者的右斜与 NES 相关。这些结果表明,特定的白质改变,即扩散性增加可能导致精神分裂症患者的 NSS。患者的主要结果显示 NES 与除 FA 在重要运动通路中的所有扩散测量呈正相关:皮质脊髓束、内囊、上纵束、丘脑皮质辐射和胼胝体。此外,探索性纤维束成像分析揭示了患者的右斜与 NES 相关。这些结果表明特定的白质改变,即增加的扩散性可能有助于精神分裂症患者的 NSS。患者的主要结果显示 NES 与除 FA 在重要运动通路中的所有扩散测量呈正相关:皮质脊髓束、内囊、上纵束、丘脑皮质辐射和胼胝体。此外,探索性纤维束成像分析揭示了患者的右斜与 NES 相关。这些结果表明,特定的白质改变,即扩散性增加可能导致精神分裂症患者的 NSS。
更新日期:2021-07-16
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