An influenza-like virus named SARS-CoV-2 is responsible for COVID-19 disease and spread worldwide within a short time. COVID-19 has now become a significant concern for public health. Obesity is highly prevalent worldwide and is considered a risk factor for impairing the adaptive immune system. Although diabetes, hypertension, cardiovascular disease, and renal failure are considered the risk factors for COVID-19, obesity is not yet well-considered. This study approaches establishing a systemic association between the prevalence of obesity and its impact on immunity concerning the severe outcomes of COVID-19 utilizing existing knowledge. Overall study outcomes documented the worldwide prevalence of obesity, its effects on immunity, and a possible underlying mechanism covering obesity-related risk pathways for the severe outcomes of COVID-19. Overall understanding from the present study is that being an immune system impairing factor, the role of obesity in the severe outcomes of COVID-19 is worthy.

中文翻译：

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肥胖是免疫力和 COVID-19 严重后果的主要危险因素。

一种名为 SARS-CoV-2 的流感样病毒导致了 COVID-19 疾病，并在短时间内在全球范围内传播。COVID-19 现在已成为公共卫生的一个重大问题。肥胖在世界范围内非常普遍，被认为是损害适应性免疫系统的危险因素。尽管糖尿病、高血压、心血管疾病和肾衰竭被认为是 COVID-19 的危险因素，但肥胖尚未得到充分考虑。本研究利用现有知识，针对 COVID-19 的严重后果，建立肥胖患病率与其对免疫力的影响之间的系统关联。总体研究结果记录了全球范围内肥胖的患病率、其对免疫力的影响，以及涵盖肥胖相关风险路径导致 COVID-19 严重后果的可能潜在机制。目前研究的总体认识是，作为一种免疫系统损害因素，肥胖在 COVID-19 的严重后果中所起的作用是值得的。