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Characterization of cognitive function in survivors of diffuse gliomas using resting-state functional MRI (rs-fMRI)
Brain Imaging and Behavior ( IF 3.2 ) Pub Date : 2021-08-05 , DOI: 10.1007/s11682-021-00497-6
Chencai Wang 1, 2 , Kathleen Van Dyk 3 , Nicholas Cho 1, 2, 4 , Catalina Raymond 1, 2 , Justin Choi 5 , Noriko Salamon 2 , Whitney B Pope 2 , Albert Lai 5 , Timothy F Cloughesy 5 , Phioanh L Nghiemphu 5 , Benjamin M Ellingson 1, 2, 3
Affiliation  

As treatments for diffuse gliomas have advanced, survival for patients with gliomas has also increased. However, there remains limited knowledge on the relationships between brain connectivity and the lasting changes to cognitive function that glioma survivors often experience long after completing treatment. This resting-state functional magnetic resonance imaging (rs-fMRI) study explored functional connectivity (FC) alterations associated with cognitive function in survivors of gliomas. In this pilot study, 22 patients (mean age 43.8 ± 11.9) with diffuse gliomas who completed treatment within the past 10 years were evaluated using rs-fMRI and neuropsychological measures. Novel rs-fMRI analysis methods were used to account for missing brain in the resection cavity. FC relationships were assessed between cognitively impaired and non-impaired glioma patients, along with self-reported cognitive impairment, non-work daily functioning, and time with surgery. In the cognitively non-impaired patients, FC was stronger in the medial prefrontal cortex, rostral prefrontal cortex, and intraparietal sulcus compared to the impaired survivors. When examining non-work daily functioning, a positive correlation with FC was observed between the accumbens and the intracalcarine cortices, while a negative correlation with FC was observed between the parietal operculum cortex and the cerebellum. Additionally, worse self-reported cognitive impairment and worse non-work daily functioning were associated with increased FC between regions involved in cognition and sensorimotor processing. These preliminary findings suggest that neural correlates for cognitive and daily functioning in glioma patients can be revealed using rs-fMRI. Resting-state network alterations may serve as a biomarker for patients’ cognition and functioning.



中文翻译:

使用静息态功能 MRI (rs-fMRI) 表征弥漫性胶质瘤幸存者的认知功能

随着弥漫性神经胶质瘤治疗的进步,神经胶质瘤患者的生存率也有所提高。然而,关于大脑连通性和神经胶质瘤幸存者在完成治疗后很长时间内经常经历的认知功能持久变化之间的关系,人们仍然知之甚少。这项静息态功能磁共振成像 (rs-fMRI) 研究探索了与神经胶质瘤幸存者认知功能相关的功能连接 (FC) 改变。在这项初步研究中,使用 rs-fMRI 和神经心理学措施对 22 名在过去 10 年内完成治疗的弥漫性胶质瘤患者(平均年龄 43.8 ± 11.9)进行了评估。新的 rs-fMRI 分析方法被用来解释切除腔中缺失的大脑。评估了认知受损和未受损神经胶质瘤患者之间的 FC 关系,以及自我报告的认知障碍、非工作日常功能和手术时间。在认知未受损的患者中,与受损的幸存者相比,FC 在内侧前额叶皮层、头侧前额叶皮层和顶内沟中更强。在检查非工作日常功能时,伏隔核和距内皮质之间观察到与 FC 正相关,而顶叶盖皮质和小脑之间观察到与 FC 负相关。此外,较差的自我报告认知障碍和较差的非工作日常功能与认知和感觉运动处理所涉及区域之间的 FC 增加有关。这些初步发现表明,可以使用 rs-fMRI 揭示神经胶质瘤患者认知和日常功能的神经相关性。静息状态网络改变可以作为患者认知和功能的生物标志物。

更新日期:2021-08-09
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