The management of the coronavirus disease 2019 pandemic will require huge worldwide vaccination efforts. In this endeavour, healthcare workers face the twofold challenge of reaching remote areas, and persuading people to take the vaccine shots. As it happens, this is nothing new in the history of medicine. Health workers can take inspiration from Francisco Xavier Balmis, a Spanish physician of the 19th century who realised the importance of Jenner's vaccine against smallpox, and led a big successful expedition to administer the vaccines in the Spanish colonial possessions of the Western hemisphere and Asia. This article presents a biographical sketch of Balmis, focusing on his expedition.

2019 年冠状病毒病大流行的管理需要全球范围内大力开展疫苗接种工作。在这一努力中，医护人员面临着双重挑战：到达偏远地区并说服人们接种疫苗。事实上，这在医学史上并不是什么新鲜事。卫生工作者可以从 19 世纪的西班牙医生弗朗西斯科·泽维尔·巴尔米斯 (Francisco Xavier Balmis) 那里得到启发，他认识到詹纳 (Jenner) 的天花疫苗的重要性，并领导了一次大规模的成功探险，在西半球和亚洲的西班牙殖民地领土上接种了疫苗。本文介绍了巴尔米斯的传记，重点介绍了他的探险活动。