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Plastic responsiveness of motor cortex to paired associative stimulation depends on cerebellar input
Clinical Neurophysiology ( IF 4.7 ) Pub Date : 2021-08-05 , DOI: 10.1016/j.clinph.2021.06.029
Asha Kishore 1 , Praveen James 1 , Traian Popa 2 , Arun Thejaus 1 , Parvathy Rajeswari 1 , Gangadhara Sarma 1 , Syam Krishnan 1 , Sabine Meunier 3
Affiliation  

Objective

The extent of plastic responses of motor cortex (M1) to paired associative stimulation (PAS) varies among healthy subjects. Continuous theta-burst stimulation (cTBS) of cerebellum enhances the mean PAS-induced plasticity in groups of healthy subjects. We tested whether the initial status of Responder or Non -Responder to PAS, influenced the effect of cerebellar stimulation on PAS-induced plasticity.

Methods

We assessed in 19 young healthy volunteers (8 Responders, 11 Non-Responders to PAS), how cTBS and iTBS (intermittent TBS) applied to the cerebellum before a PAS protocol influenced the plastic responsiveness of M1 to PAS. We tested whether the PAS-induced plastic effects could be depotentiated by a short cTBS protocol applied to M1 shortly after PAS and whether cerebellar stimulation influenced GABA-ergic intracortical inhibition and M1 plasticity in parallel.

Results

Cerebellar cTBS restored the M1 response to PAS in Non-Responders while cerebellar iTBS turned the potentiating response to PAS to a depressive response in both groups. The depotentiation protocol abolished both responses.

Conclusion

Non-Responder status to PAS is a state of M1 amenable to bidirectional plastic modulation when primed by a change in cerebello-thalamic drive.

Significance

The meaning of lack of responsiveness to certain protocols probing plasticity should be reconsidered.



中文翻译:

运动皮层对成对联想刺激的塑性反应取决于小脑输入

客观的

运动皮层 (M1) 对配对联想刺激 (PAS) 的塑性反应程度因健康受试者而异。小脑的连续 theta-burst 刺激 (cTBS) 增强了健康受试者组的平均 PAS 诱导的可塑性。我们测试了响应者或非响应者对 PAS 的初始状态是否影响小脑刺激对 PAS 诱导的可塑性的影响。

方法

我们评估了 19 名年轻健康志愿者(8 名响应者,11 名 PAS 非响应者),在 PAS 协议影响 M1 对 PAS 的塑性响应之前,cTBS 和 iTBS(间歇性 TBS)如何应用于小脑。我们测试了 PAS 诱导的塑性效应是否可以通过在 PAS 后不久应用于 M1 的短 cTBS 协议来减弱,以及小脑刺激是否同时影响 GABA 能皮质内抑制和 M1 可塑性。

结果

小脑 cTBS 恢复了无应答者对 PAS 的 M1 反应,而小脑 iTBS 将两组对 PAS 的增强反应转变为抑郁反应。去潜能方案废除了这两种反应。

结论

PAS 的非响应者状态是一种 M1 状态,当由小脑 - 丘脑驱动的变化启动时,可以进行双向塑性调制。

意义

应该重新考虑对某些探索可塑性的协议缺乏响应的含义。

更新日期:2021-08-26
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