In this issue of Cell Stem Cell, Hormaechea-Agulla et al. (2021) demonstrate that IFNγ signaling following an infection in mice provides a selective pressure that drives growth of Dnmt3a^−/− hematopoietic stem cells. This clonal expansion is mediated by global methylation changes that lead to an increased self-renewing capacity.

中文翻译：

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感染使微芯片变成宏芯片

在本期《细胞干细胞》中，Hormaechea-Agulla 等人。(2021) 证明小鼠感染后的 IFNγ 信号传递提供了一种选择压力，可以驱动Dnmt3a ^-/-造血干细胞的生长。这种克隆扩张是由导致自我更新能力增强的全球甲基化变化介导的。