Low fetal fraction (LFF) in prenatal cell-free DNA (cfDNA) testing is an important cause of test failure and no-call results. LFF might reflect early abnormal placentation and therefore be associated with adverse pregnancy outcome. Here, we review the available literature on the relationship between LFF in cfDNA testing and adverse pregnancy outcome.

中文翻译：

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无细胞 DNA 检测中低胎儿分数与不良妊娠结局之间的关联：系统评价

产前无细胞 DNA (cfDNA) 检测中的低胎儿分数 (LFF) 是检测失败和无呼叫结果的重要原因。LFF 可能反映早期异常胎盘，因此与不良妊娠结局相关。在这里，我们回顾了有关 cfDNA 检测中 LFF 与不良妊娠结局之间关系的现有文献。