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Long non-coding RNAs orchestrate various molecular and cellular processes by modulating epithelial-mesenchymal transition in head and neck squamous cell carcinoma
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ( IF 6.2 ) Pub Date : 2021-08-05 , DOI: 10.1016/j.bbadis.2021.166240
Ayushi Sharma 1 , Samarth Kansara 1 , Mehul Mahajan 2 , Bhupender Yadav 1 , Manoj Garg 3 , Amit Kumar Pandey 1
Affiliation  

Long noncoding RNAs (lncRNAs) regulate various hallmarks associated with the progression of human cancers through their binding with RNA, DNA, and proteins. Epithelial-Mesenchymal Transition (EMT) is a cardinal and multi-stage process where epithelial cells acquire a mesenchymal-like phenotype that is instrumental for tumor cells to initiate invasion and metastasis. LncRNAs can potentially promote tumor onset and progression as well as drug resistance by directly or indirectly altering the EMT program. Head and neck squamous cell carcinoma (HNSCC) are a dreadful malignancy affecting public health globally. The past few years have provided a better insight into the mechanism of EMT in HNSCC. The differential expression of the lncRNAs that can act either as promoters or suppressors in the process of EMT is of great importance. In this review, we aim to sum up, the highly structured mechanism with the diverse role of lncRNAs and their interaction with different molecules in the regulation of EMT. Moreover, discussing principal EMT pathways modulated by lncRNAs and their prospective potential value as therapeutic targets.



中文翻译:

长链非编码 RNA 通过调节头颈部鳞状细胞癌的上皮间质转化来协调各种分子和细胞过程

长链非编码 RNA (lncRNA) 通过与 RNA、DNA 和蛋白质的结合来调节与人类癌症进展相关的各种标志。上皮-间充质转化 (EMT) 是一个重要的多阶段过程,其中上皮细胞获得间充质样表型,这有助于肿瘤细胞启动侵袭和转移。LncRNA 可以通过直接或间接改变 EMT 程序来潜在地促进肿瘤的发生和进展以及耐药性。头颈部鳞状细胞癌 (HNSCC) 是一种可怕的恶性肿瘤,影响全球公共卫生。过去几年对 HNSCC 中 EMT 的机制有了更好的了解。在 EMT 过程中可以作为启动子或抑制子的 lncRNA 的差异表达非常重要。在这次审查中,我们的目标是总结出 lncRNA 的多种作用及其与不同分子相互作用在 EMT 调控中的高度结构化机制。此外,讨论了 lncRNA 调节的主要 EMT 途径及其作为治疗靶点的潜在价值。

更新日期:2021-08-09
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