Abstract

The appreciation of human microbiome is gaining strong grounds in biomedical research. In addition to gut-brain axis, is the lung-brain axis, which is hypothesised to link pulmonary microbes to neurodegenerative disorders and behavioural changes. There is a need for analysis based on emerging studies to map out the prospects for lung-brain axis. In this review, relevant English literature and researches in the field of ‘lung-brain axis’ is reported. We recommend all the highlighted prospective studies to be integrated with an interdisciplinary approach. This might require conceptual research approaches based on physiology and pathophysiology. Multimodal aspects should include experimental animal units, while exploring the research gaps and making reference to the already existing human data. The overall microbiome medicine is gaining more ground. Aetiological paths and experimental recommendations as per prospective studies in this review will be an important guideline to develop effective treatments for any lung induced neurodegenerative diseases. An in-depth knowledge of the bi-directional communication between host and microbiome in the lung could help treatment to respiratory infections, alleviate stress, anxiety and enhanced neurological effects. The timely prevention and treatment of neurodegenerative diseases requires paradigm shift of the aetiology and more innovative experimentation.

• Impact statement

• The overall microbiome medicine is gaining more ground. An in-depth knowledge of the bi-directional communication between host and microbiome in the lung could confer treatment to respiratory infections, alleviate stress, anxiety and enhanced neurological effects. Based on this review, we recommend all the highlighted prospective studies to be integrated and be given an interdisciplinary approach. This might require conceptual research approaches based on physiology and pathophysiology. Multimodal aspects should include experimental animal units; while exploring the research gaps and making reference to the already existing human data.

摘要

对人类微生物组的认识在生物医学研究中获得了坚实的基础。除了肠-脑轴之外，还有肺-脑轴，它被假设将肺部微生物与神经退行性疾病和行为改变联系起来。需要基于新兴研究进行分析，以绘制出肺脑轴的前景。在这篇综述中，报道了“肺脑轴”领域的相关英文文献和研究。我们建议将所有突出显示的前瞻性研究与跨学科方法相结合。这可能需要基于生理学和病理生理学的概念研究方法。多模式方面应包括实验动物单元，同时探索研究空白并参考已有的人类数据。整个微生物组医学正在获得更多的支持。根据本综述中的前瞻性研究，病因学路径和实验建议将成为开发任何肺诱发神经退行性疾病的有效治疗方法的重要指南。深入了解肺部宿主和微生物组之间的双向交流有助于治疗呼吸道感染、缓解压力、焦虑和增强神经系统影响。及时预防和治疗神经退行性疾病需要病因学的范式转变和更多的创新实验。深入了解肺部宿主和微生物组之间的双向交流有助于治疗呼吸道感染、缓解压力、焦虑和增强神经系统影响。及时预防和治疗神经退行性疾病需要病因学的范式转变和更多的创新实验。深入了解肺部宿主和微生物组之间的双向交流有助于治疗呼吸道感染、缓解压力、焦虑和增强神经系统影响。及时预防和治疗神经退行性疾病需要病因学的范式转变和更多的创新实验。

• 影响陈述

• 整个微生物组医学正在获得更多的支持。深入了解肺部宿主和微生物组之间的双向交流可以治疗呼吸道感染、缓解压力、焦虑和增强神经系统影响。根据这篇综述，我们建议整合所有突出的前瞻性研究，并采用跨学科方法。这可能需要基于生理学和病理生理学的概念研究方法。多模式方面应包括实验动物单元；同时探索研究空白并参考已有的人类数据。