Six novel copper(II) complexes with the non–steroidal anti–inflammatory drugs ibuprofen, loxoprofen, fenoprofen and clonixin as ligands were synthesized and characterized by diverse techniques including single–crystal X–ray crystallography. The in vitro scavenging activity of the complexes against 1,1–diphenyl–picrylhydrazyl and 2,2′–azinobis(3–ethylbenzothiazoline–6–sulfonic acid) free radicals and the ability to reduce H₂O₂ were studied in the context of the antioxidant activity studies. The complexes may interact with calf–thymus DNA via intercalation as revealed by the techniques employed. The affinity of the complexes for bovine and human serum albumins was evaluated by fluorescence emission spectroscopy and the corresponding binding constants were determined. Molecular docking simulations on the crystal structure of calf–thymus DNA, human and bovine serum albumins were also employed in order to study in silico the ability of the studied compounds to bind to these target biomacromolecules, in terms of impairment of DNA and transportation through serum albumins, to explain the observed in vitro activity and to establish a possible mechanism of action.

合成了六种以非甾体抗炎药布洛芬、洛索洛芬、非诺洛芬和可乐宁为配体的新型铜 (II) 配合物，并通过包括单晶 X 射线晶体学在内的多种技术对其进行了表征。在体外研究了配合物对 1,1-二苯基-苦基肼和 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) 自由基的体外清除活性和还原 H 2 O ₂的_能力。抗氧化活性研究。复合物可能通过以下途径与小牛胸腺 DNA 相互作用所采用的技术所揭示的嵌入。通过荧光发射光谱评估复合物对牛和人血清白蛋白的亲和力并确定相应的结合常数。还采用了对小牛胸腺 DNA、人和牛血清白蛋白的晶体结构的分子对接模拟，以便在计算机上研究所研究的化合物与这些目标生物大分子结合的能力，即 DNA 的损伤和通过血清的运输白蛋白，以解释观察到的体外活性并建立可能的作用机制。