Abstract

Background

Substance Use Disorder is a chronic relapsing disease that is characterized by compulsive drug seeking and use, despite harmful consequences. The aim of this study was to evaluate the impact of clinical pharmacist intervention/recommendation on the treatment of patients admitted to addiction rehabilitation centers in Jordan.

Methods

A randomized controlled trial was conducted in two public addiction treatment centers in Amman. Patients (n = 93) were randomized into 2 groups (control and intervention). Medication review was conducted for both groups at baseline, during stay and at discharge. Treatment related problems (TRPs) were identified by the clinical pharmacist and recommendations provided to the therapeutic team in the intervention group. Additionally, quality of life and quality of sleep were assessed at baseline and 2 weeks later.

Results

A total of 392 TRPs were identified during the study period. The mean number of TRPs ± SD was 4.22 ± 2.58 per patient. The clinical pharmacist intervention led to a reduction in the mean number of TRPs at discharge by 2.2 ± 0.85 (p < 0.001) in comparison to the control group (by 0.23 ± 0.27, p = 0.066). After 2 weeks of admission, there was an improvement of physical health (p = 0.035) and of the overall sleep status (p = 0.048) in the intervention vs. control groups.

Conclusion

Clinical pharmacy services provided to patients with substance use disorder reduced the number of TRPs and improved other outcomes such as physical health and quality of sleep during detoxification. Long term studies with larger sample sizes are needed.

中文翻译：

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约旦药物使用障碍治疗中的药学服务：一项随机对照试验

摘要

背景

物质使用障碍是一种慢性复发性疾病，其特征是强迫性地寻求和使用药物，尽管会产生有害后果。本研究的目的是评估临床药师干预/建议对约旦成瘾康复中心入院患者治疗的影响。

方法

在安曼的两个公共成瘾治疗中心进行了一项随机对照试验。患者 ( n  = 93) 被随机分为 2 组（对照组和干预组）。在基线、住院期间和出院时对两组进行药物审查。临床药师确定治疗相关问题 (TRP)，并向干预组的治疗团队提供建议。此外，在基线和 2 周后评估了生活质量和睡眠质量。

结果

在研究期间共确定了 392 个 TRP。TRPs ± SD 的平均数为每位患者 4.22 ± 2.58。 与对照组（0.23 ± 0.27，p  = 0.066）相比，临床药师干预导致出院时 TRP​​ 的平均数量减少了 2.2 ± 0.85 ( p < 0.001 )。入院 2 周后， 干预组与对照组的身体健康状况 ( p  = 0.035) 和整体睡眠状态 ( p = 0.048)有所改善。

结论

为物质使用障碍患者提供的临床药学服务减少了 TRP 的数量并改善了其他结果，例如身体健康和排毒期间的睡眠质量。需要更大样本量的长期研究。