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Lifestyle-dependent microglial plasticity: training the brain guardians
Biology Direct ( IF 5.5 ) Pub Date : 2021-08-05 , DOI: 10.1186/s13062-021-00297-4
Marcus Augusto-Oliveira 1 , Alexei Verkhratsky 2, 3, 4, 5
Affiliation  

Lifestyle is one of the most powerful instruments shaping mankind; the lifestyle includes many aspects of interactions with the environment, from nourishment and education to physical activity and quality of sleep. All these factors taken in complex affect neuroplasticity and define brain performance and cognitive longevity. In particular, physical exercise, exposure to enriched environment and dieting act through complex modifications of microglial cells, which change their phenotype and modulate their functional activity thus translating lifestyle events into remodelling of brain homoeostasis and reshaping neural networks ultimately enhancing neuroprotection and cognitive longevity.

中文翻译:

生活方式相关的小胶质细胞可塑性:训练大脑守护者

生活方式是塑造人类最强大的工具之一;生活方式包括与环境相互作用的许多方面,从营养和教育到体育活动和睡眠质量。所有这些综合因素都会影响神经可塑性并定义大脑性能和认知寿命。特别是,体育锻炼、接触丰富的环境和节食通过对小胶质细胞的复杂修饰起作用,从而改变它们的表型并调节它们的功能活动,从而将生活方式事件转化为大脑稳态的重塑和重塑神经网络,最终增强神经保护和认知寿命。
更新日期:2021-08-05
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