An efficient protocol for the selective synthesis of (acyloxymethylidene)chromonyl-furochromones or amido-(acyloxymethylidene)chromones via a water-controlled multicomponent cascade reaction of 3-formylchromones, linear carboxylic acid anhydrides, and alkyl isocanides in CH₂Cl₂ has been developed. (Acyloxymethylidene)chromonyl-furochromones were obtained in dry CH₂Cl₂; conversely, amido-(acyloxymethylidene)chromones were formed with wet CH₂Cl₂ (undried dichloromethane) as the solvent at room temperature. The reaction proceeds via the formation of a highly reactive O-acylatedoxonium intermediate, generated from the reaction between 3-formylchromones and linear carboxylic acid anhydrides. The subsequent trapping of the O-acylatedoxonium ion by aminofurochromone intermediate in situ generated by cycloaddition reaction of alkyl isocyanide and the second equivalent of 3-formylchromone in dry CH₂Cl₂, would give (acyloxymethylidene)chromonyl-furochromones in excellent diastereoselectivity and yields. Alternatively, O-acylatedoxonium intermediate could be also regioselectively trapped by α-addition of alkyl isocyanides in wet CH₂Cl₂ to provide amido-(acyloxymethylidene)chromones in good yields.

对的（acyloxymethylidene）chromonyl-furochromones或酰氨基（acyloxymethylidene）色酮的选择性合成的高效的协议经由3- formylchromones水控制的多组分级联反应，直链羧酸酐，并在CH烷基isocanides ₂氯₂已经开发. (酰氧基亚甲基)色酰基-呋喃色酮在干燥CH ₂ Cl _{2 中获得}；相反，在室温下用湿CH ₂ Cl ₂ (未干燥二氯甲烷)作为溶剂形成酰氨基-(酰氧基亚甲基)色酮。反应通过形成高反应性的O-酰化氧鎓中间体，由 3-甲酰基色酮和线性羧酸酐反应生成。的随后的俘获ö通过aminofurochromone中间-acylatedoxonium离子原位被烷基异腈的环化加成反应和3-甲酰基色的无水CH第二等效产生₂氯₂，将给出在非对映选择性优良和产率（acyloxymethylidene）chromonyl-furochromones。或者，O-酰化氧鎓中间体也可以通过烷基异氰化物在湿CH ₂ Cl _{2 中}的α-加成来区域选择性地捕获，从而以良好的产率提供酰氨基-(酰氧基亚甲基)色酮。