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Prognostic and Clinicopathologic Significance of Discoidin Domain Receptors in Different Human Malignancies: A Meta-Analysis
Gastrointestinal Tumors Pub Date : 2021-08-05 , DOI: 10.1159/000517503
Gordon A Ferns 1 , Sheida Shabanian 2 , Milad Shahini Shams Abadi 3 , Ahmadshah Farhat 4 , Mohammad-Hassan Arjmand 5, 6
Affiliation  

Background: Discoidin domain receptors (DDRs) belong to the receptor tyrosine kinases family and are activated by different types of collagens, which play roles in various physiological processes. An abnormal expression of DDRs is reported in different types of cancers. Despite many reports about the association and roles of high DDR expression levels in cancers, the prognostic values of DDRs are still unclear. This meta-analysis was performed to evaluate the prognostic effect of DDRs in different tissue cancers. Method: A literature search was performed in several related databases to find eligible English articles. Based on our research, 20 appropriate studies with 2,602 patients were selected till October 5, 2020. The pooled hazard ratio (HR) with a corresponding 95% confidence interval (CI) was computed to evaluate the strength of correlation between DDRs and survival of cancer patients. Result: Pooling results showed that a high DDR expression was significantly associated with poorer overall survival (OS) (HR = 1.304, 95% CI 1.007–1.69, p = 0.04). Subgroup analysis based on cancer type revealed a significant link between a high DDR expression level and poor OS both in gastrointestinal (pooled HR = 1.78, 95% CI 1.214–2.624, p = 0.003) and urological cancers (pooled HR = 1.42, 95% CI 1.062–1.82, p = 0.018). Conclusion: Our meta-analysis results suggest that high DDRs expression has the potential to be used as a biomarker of poor prognosis in cancers.
Gastrointest Tumors


中文翻译:

盘状结构域受体在不同人类恶性肿瘤中的预后和临床病理学意义:荟萃分析

背景:盘状结构域受体 (DDRs) 属于受体酪氨酸激酶家族,由不同类型的胶原蛋白激活,在各种生理过程中发挥作用。在不同类型的癌症中报告了 DDR 的异常表达。尽管有许多关于高 DDR 表达水平在癌症中的关联和作用的报道,但 DDR 的预后价值仍不清楚。这项荟萃分析旨在评估 DDR 在不同组织癌症中的预后作用。方法:在几个相关数据库中进行了文献检索,以找到符合条件的英文文章。根据我们的研究,截至 2020 年 10 月 5 日,选择了 20 项适当的研究,涉及 2,602 名患者。计算了具有相应 95% 置信区间 (CI) 的汇总风险比 (HR),以评估 DDR 与癌症生存率之间的相关强度耐心。结果:汇总结果显示,高 DDR 表达与较差的总生存期 (OS) 显着相关(HR = 1.304, 95% CI 1.007–1.69, p = 0.04)。基于癌症类型的亚组分析揭示了高 DDR 表达水平与胃肠道中较差的 OS 之间存在显着联系(合并 HR = 1.78, 95% CI 1.214–2.624, p= 0.003)和泌尿系统癌症(合并 HR = 1.42, 95% CI 1.062–1.82, p = 0.018)。结论:我们的荟萃分析结果表明,DDRs 的高表达有可能用作癌症预后不良的生物标志物。
胃肠肿瘤
更新日期:2021-08-05
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