Clostridioides difficile infection (CDI) in children with inflammatory bowel disease (IBD) can present and manifest differently from the general population with CDI, and it can worsen the underlying disease course. Furthermore, current clinical assays used to test for CDI do not accurately distinguish between true CDI or colonization. This uncertainty leads to difficulty in identifying the etiology and therapy for symptomatic patients with IBD. Improved diagnostic tests, biomarkers, and safe and effective treatment options are greatly needed for this vulnerable population.

中文翻译：

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小儿炎症性肠病中的艰难梭菌感染：临床医生的困境。

患有炎症性肠病 (IBD) 的儿童的艰难梭菌感染 (CDI) 的表现和表现可能与患有 CDI 的普通人群不同，它可能会加重潜在的病程。此外，目前用于测试 CDI 的临床试验不能准确地区分真正的 CDI 或定植。这种不确定性导致难以确定有症状的 IBD 患者的病因和治疗方法。这个弱势群体非常需要改进的诊断测试、生物标志物以及安全有效的治疗方案。