Searching for drug carries with controlled release and good biocompatibility has always been one of the research hotspots and difficulties. Herein, core–sheath nanofibrous mats (NFs) consisting of biocompatible poly(ethylene oxide) (PEO, core) and poly(l-lactic acid) (PLLA, sheath) for drug delivery were fabricated via coaxial electrospinning strategy. The nontoxic layered silicate rectorite (REC) with 0.5–1 wt % amount was introduced in the sheath for sustained drug delivery. Layered REC could be intercalated with PLLA macromolecule chains, leading to the densified structure for loading and keeping doxorubicin hydrochloride (DOX) while reversibly capturing and releasing DOX to delay the drug migration due to its high cation activity. The addition of REC in NFs could delay the initial burst release of DOX and prolong the residence time from 12 to 96 h. Moreover, DOX-loaded core–sheath NFs had in vitro culture with strong antitumor activity, which was confirmed by cytotoxicity results and live and dead assay. HepG₂ tumor-bearing xenograft further demonstrated the tumor-suppression effect and the excellent safety of the DOX-loaded core–sheath NFs in vivo. The constructed NFs as drug carriers showed great potential in the local treatment of solid tumors.

中文翻译：

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将层状 Rectorite 掺入生物相容的核-鞘纳米纤维垫中，用于持续给药

寻找具有控释性和良好生物相容性的药物载体一直是研究的热点和难点之一。在此，由生物相容性聚（环氧乙烷）（PEO，核心）和聚（l-乳酸）（PLLA，鞘）用于药物递送是通过同轴静电纺丝策略制造的。将 0.5-1 wt% 的无毒层状硅酸盐雷托石 (REC) 引入鞘中，以实现持续的药物输送。层状 REC 可以插入 PLLA 大分子链，导致负载和保持盐酸多柔比星 (DOX) 的致密结构，同时由于其高阳离子活性，可逆地捕获和释放 DOX 以延迟药物迁移。在 NFs 中添加 REC 可以延迟 DOX 的初始爆发释放，并将停留时间从 12 小时延长到 96 小时。此外，载有 DOX 的核-鞘 NFs在体外培养具有很强的抗肿瘤活性，这通过细胞毒性结果和活体和死体试验得到证实。HepG ₂荷瘤异种移植物进一步证明了载有 DOX 的核鞘 NFs的体内肿瘤抑制作用和优异的安全性。构建的NFs作为药物载体在实体瘤的局部治疗中显示出巨大的潜力。