Emerging evidence has suggested that metformin may be protective against the development of human-papillomavirus-related cancers. Anal intraepithelial neoplasia (AIN) is highly associated with human papillomavirus infection and a precancerous status of anal cancer. The aim of this study was to investigate the relationship between metformin usage and the development of AIN in a large national sample.

中文翻译：

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II型糖尿病患者使用二甲双胍和肛门上皮内瘤变的风险

新出现的证据表明，二甲双胍可能对人乳头瘤病毒相关癌症的发展具有保护作用。肛门上皮内瘤变（AIN）与人乳头瘤病毒感染和肛门癌的癌前状态高度相关。本研究的目的是在全国大样本中调查二甲双胍使用与 AIN 发展之间的关系。