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Clinical evaluation and diagnosis of aspirin-exacerbated respiratory disease
Journal of Allergy and Clinical Immunology ( IF 14.2 ) Pub Date : 2021-08-04 , DOI: 10.1016/j.jaci.2021.06.018
Rubaiyat Haque 1 , Andrew A White 2 , David J Jackson 3 , Claire Hopkins 4
Affiliation  

Aspirin-exacerbated respiratory disease (AERD) is a condition composed of chronic rhinosinusitis with nasal polyposis and asthma that is defined by respiratory hypersensitivity reactions to the cyclooxygenase 1–inhibitory effects of nonsteroidal anti-inflammatory drugs. It is diagnosed in 5% to 15% of patients with asthma and is even more common in those with comorbid nasal polyposis. Diagnosis is confirmed after an aspirin challenge procedure, yet many patients present with all components and can reliably be diagnosed by history. Patients with AERD commonly experience severe uncontrolled nasal polyposis and require multispecialty evaluation to properly stage and treat this condition. The presence of nasal polyposis plays a large component in the diminished quality of life in patients with AERD. In the last decade, multiple new therapeutic areas have been approved for type 2 airway diseases, offering patients with AERD many more options for control. This makes an early and accurate diagnosis of AERD important in the care of the larger population of type 2 airway diseases.



中文翻译:

阿司匹林加重呼吸系统疾病的临床评价与诊断

阿司匹林加重性呼吸系统疾病 (AERD) 是一种由慢性鼻窦炎伴鼻息肉病和哮喘组成的疾病,其定义为对非甾体抗炎药的环氧合酶 1 抑制作用的呼吸道过敏反应。在 5% 至 15% 的哮喘患者中被诊断出患有此病,在患有鼻息肉病的患者中更为常见。诊断是在阿司匹林激发程序后确认的,但许多患者表现出所有成分并且可以通过病史可靠地诊断。AERD 患者通常会出现严重的不受控制的鼻息肉病,需要多专业评估才能正确分期和治疗这种情况。鼻息肉病的存在在 AERD 患者的生活质量下降中起着重要作用。在过去的十年里,多个新的治疗领域已被批准用于 2 型气道疾病,为 AERD 患者提供了更多的控制选择。这使得 AERD 的早期准确诊断对于治疗更多的 2 型气道疾病非常重要。

更新日期:2021-08-04
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