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Using the Relationship between Concentrations of Selected Whey Proteins and BHBA to Characterize the Metabolism of Dairy Cows in Early Lactation
Animals ( IF 3 ) Pub Date : 2021-08-04 , DOI: 10.3390/ani11082298
Kamila Puppel 1 , Patrycja Staniszewska 1 , Marcin Gołębiewski 1 , Jan Slósarz 1 , Grzegorz Grodkowski 1 , Paweł Solarczyk 1 , Małgorzata Kunowska-Slósarz 1 , Piotr Kostusiak 1 , Beata Kuczyńska 1 , Tomasz Przysucha 1
Affiliation  

A negative energy balance alters the concentration of various fractions of cows’ milk. Therefore, by analyzing the concentration of individual proteins in milk, it is possible to indirectly monitor the health of the animal. The aim of the present study was to identify the relationship between the concentrations of blood β-hydroxybutyric acid (BHBA) and whey proteins in milk as a marker for the diagnosis of metabolic diseases. The analysis included milk and blood samples from 95 Holstein-Friesian cows, which were divided into three groups that were differentiated in terms of serum BHBA levels 5–7 days post-calving: LBHBA, low level of BHBA: 0.200–0.500 mmol/L; NBHBA, optimal level of BHBA- control group: 0.500–1.200 mmol/L; HBHBA, high level of BHBA: >1.200 mmol/L. Concentrations of α-lactoalbumin in the milk after 7 days of lactation proceeded in accordance with the concentration of β-hydroxybutyric acid, as follows: LBHBA > NBHBA > HBHBA. Concentrations of β-lactoglobulin in milk after 14 days of lactation proceeded in accordance with the concentration of β-hydroxybutyric acid, as follows: LBHBA < NBHBA < HBHBA. Therefore, it can be concluded that whey proteins can be used as non-invasive markers for diagnosing metabolic diseases. A high concentration of β-lactoglobulin can be a marker for diagnosing ketosis. Conversely, elevated levels of α-lactalbumin may indicate the occurrence of a metabolic disorder, such as acidosis.

中文翻译:

利用所选乳清蛋白浓度与 BHBA 之间的关系来表征泌乳早期奶牛的代谢

负能量平衡会改变牛奶各部分的浓度。因此,通过分析牛奶中单个蛋白质的浓度,可以间接监测动物的健康状况。本研究的目的是确定血液 β-羟基丁酸 (BHBA) 和牛奶中乳清蛋白的浓度之间的关系,作为诊断代谢疾病的标志物。分析包括来自 95 头荷斯坦 - 弗里斯兰奶牛的牛奶和血液样本,根据产犊后 5-7 天的血清 BHBA 水平将其分为三组:LBHBA,低水平 BHBA:0.200-0.500 mmol/L ; NBHBA,BHBA-对照组最佳水平:0.500-1.200 mmol/L;HBHBA,高水平的 BHBA:>1.200 mmol/L。哺乳 7 天后牛奶中 α-乳白蛋白的浓度与 β-羟基丁酸的浓度一致,如下:LBHBA > NBHBA > HBHBA。泌乳 14 天后牛奶中 β-乳球蛋白的浓度按照 β-羟基丁酸的浓度进行,如下所示:LBHBA < NBHBA < HBHBA。因此,可以得出结论,乳清蛋白可以作为诊断代谢疾病的非侵入性标志物。高浓度的 β-乳球蛋白可以作为诊断酮症的标志物。相反,α-乳清蛋白水平升高可能表明代谢紊乱的发生,如酸中毒。泌乳 14 天后牛奶中 β-乳球蛋白的浓度按照 β-羟基丁酸的浓度进行,如下所示:LBHBA < NBHBA < HBHBA。因此,可以得出结论,乳清蛋白可以作为诊断代谢疾病的非侵入性标志物。高浓度的 β-乳球蛋白可以作为诊断酮症的标志物。相反,α-乳清蛋白水平升高可能表明代谢紊乱的发生,如酸中毒。泌乳 14 天后牛奶中 β-乳球蛋白的浓度按照 β-羟基丁酸的浓度进行,如下所示:LBHBA < NBHBA < HBHBA。因此,可以得出结论,乳清蛋白可以作为诊断代谢疾病的非侵入性标志物。高浓度的 β-乳球蛋白可以作为诊断酮症的标志物。相反,α-乳清蛋白水平升高可能表明代谢紊乱的发生,如酸中毒。
更新日期:2021-08-04
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