An efficient visible-light-induced alkylation of DNA-tagged quinoxaline-2-ones was described. The methodology demonstrated moderate-to-excellent conversions under mild conditions. The reaction was found to be tolerant with both N-protected α-amino acids and aliphatic carboxylic acids and could be applied to the synthesis of focused DNA-encoded quinoxalin-2-one libraries.

中文翻译：

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通过可见光触发的羧酸烷基化对喹喔啉-2-酮进行 DNA 上衍生化

描述了 DNA 标记的 quinoxaline-2-ones 的有效可见光诱导烷基化。该方法在温和条件下显示出中等至优异的转化率。发现该反应对N保护的 α-氨基酸和脂肪族羧酸都具有耐受性，可用于合成 DNA 编码的 quinoxalin-2-one 文库。