Changes in anterior segment parameters and presence of dry eye disease in patients with acromegaly: A Sirius topography study combined with meibography,Growth Hormone and IGF Research

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Changes in anterior segment parameters and presence of dry eye disease in patients with acromegaly: A Sirius topography study combined with meibography
Growth Hormone and IGF Research ( IF 1.4 ) Pub Date : 2021-08-04 , DOI: 10.1016/j.ghir.2021.101424
Deniz Kilic ₁ , Berkay Akmaz ₂ , Fahrettin Akay ₃ , Yusuf Ziya Guven ₄ , Guzide Gonca Oruk ₅

Affiliation

Purpose

To investigate anterior segment parameters (ASPs) and dry eye disease (DED), including the status of the meibomian glands, in patients with acromegaly.

Methods

In this cross-sectional, comparative study, 36 acromegaly patients and 40 healthy sex- and age-matched controls were included. Participants received a comprehensive ophthalmological examination, including intraocular pressure measurements with Goldmann applanation tonometry (IOP_GAT) and central corneal thickness corrected intraocular pressure (IOP_CCT) measurements, and were evaluated for ASPs and DED. For ASPs, white-to-white (WTW), apical (ACT) and thinnest corneal thickness (TCT), corneal volume (CV), keratometry readings (K₁, K₂, and K_mean), anterior chamber depth (ACD) and volume (ACV), and iridocorneal angle (ICA) were obtained via Sirius topography. DED was assessed with Schirmer's test, tear breakup time (TBUT), and Ocular Surface Disease Index (OSDI) scores. Meibography scores (MSs) were obtained with the Sirius topography device.

Results

Patients had higher mean IOP_GAT (P = .006), IOP_CCT (P = .01), ACT (P = .024), and TCT (P = .005) but narrower ICA (P = .014) than controls. Although Schirmer's test did not differ between the groups (P = .442), patients had higher OSDI (P < .001), higher MS (P = .001), and shorter TBUT (P = .002).

Conclusion

Patients with acromegaly have greater IOP, greater corneal thickness, but narrower ICA than healthy individuals, as well as DED with increased MSs, which suggests meibomian gland dysfunction.

中文翻译：

肢端肥大症患者眼前节参数的变化和干眼症的存在：Sirius 地形图研究与 meibography 相结合

目的

调查肢端肥大症患者的眼前节参数 (ASP) 和干眼病 (DED)，包括睑板腺的状态。

方法

在这项横断面比较研究中，包括 36 名肢端肥大症患者和 40 名健康的性别和年龄匹配的对照。参与者接受了全面的眼科检查，包括使用 Goldmann 压平眼压计 (IOP _GAT ) 测量眼压和中央角膜厚度校正眼压 (IOP _CCT ) 测量，并评估 ASP 和 DED。对于 ASP，白变白 (WTW)、顶端 (ACT) 和最薄角膜厚度 (TCT)、角膜体积 (CV)、角膜曲率读数（K ₁、K ₂和 K_平均值)、前房深度 (ACD) 和容积 (ACV) 以及虹膜角膜角 (ICA) 是通过 Sirius 地形图获得的。使用 Schirmer 测试、泪液破裂时间 (TBUT) 和眼表疾病指数 (OSDI) 评分评估 DED。使用 Sirius 地形设备获得了 Meibography 分数 (MS)。

结果

与对照组相比，患者的平均 IOP _GAT ( P = .006)、IOP _CCT ( P = .01)、ACT ( P = .024) 和 TCT ( P = .005) 更高，但 ICA 更窄 ( P = .014)。虽然 Schirmer 的检验在各组之间没有差异 ( P = .442)，但患者的 OSDI 较高 ( P < .001)、MS 较高 ( P = 0.001) 和 TBUT 较短 ( P = 0.002)。