Today, bacterial cellulose has received a great deal of attention for its medical applications due to its unique structural properties such as high porosity, good fluid uptake, good strength, and biocompatibility. This study aimed to fabricate and study bacterial cellulose/graphitic carbon nitride/nettles/trachyspermum nanocomposite by immersion and PVA/BC/g-C₃N₄/nettles/trachyspermum nanofiber by electrospinning method as a wound dressing. The g-C₃N₄ and g-C₃N₄ solution were synthesized and then were characterized using Fourier transform infrared, X-ray diffraction, Zeta Potential, and scanning electronic microscope analyzes. Also, the antibacterial properties of the synthesized materials were proved by gram-positive and gram-negative bacteria using the minimum inhibitory concentration method. Besides, the toxicity, migration, and cell proliferation results of the synthesized materials on NIH 3T3 fibroblasts were evaluated using MTT and scratch assays and showed that the BC/PVA/g-C₃N₄/nettles/trachyspermum composite not only had no toxic effect on cells but also contributed to cell survival, cell migration, and proliferation has done. To evaluate the mechanical properties, a tensile strength test was performed on PVA/BC/g-C₃N₄/nettles/trachyspermum nanofibers, and the results showed good strength of the nanocomposite. In addition, in vivo assay, the produced nanofibers were used to evaluate wound healing, and the results showed that these nanofibers were able to accelerate the wound healing process so that after 14 days, the wound healing percentage showed 95%. Therefore, this study shows that PVA/BC/g-C₃N₄/nettles/trachyspermum nanofibers effectively inhibit bacterial growth and accelerate wound healing.

中文翻译：

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含有石墨氮化碳/荨麻/粗精修饰纤维素的 PVA 基纳米纤维可加速伤口愈合

如今，细菌纤维素因其独特的结构特性（如高孔隙率、良好的流体吸收性、良好的强度和生物相容性）而在医学应用中受到了广泛关注。本研究旨在通过浸渍法制备和研究细菌纤维素/石墨氮化碳/荨麻/粗精纳米复合材料，并通过静电纺丝法制备和研究PVA/BC/gC ₃ N ₄ /荨麻/粗精纳米纤维作为伤口敷料。gC ₃ N ₄和 gC ₃ N ₄合成溶液，然后使用傅里叶变换红外、X 射线衍射、Zeta 电位和扫描电子显微镜分析进行表征。此外，采用最小抑菌浓度法对革兰氏阳性菌和革兰氏阴性菌证明了合成材料的抗菌性能。此外，使用MTT和划痕试验评估合成材料对NIH 3T3成纤维细胞的毒性、迁移和细胞增殖结果，表明BC/PVA/gC ₃ N ₄ /荨麻/粗精复合物不仅对NIH 3T3成纤维细胞没有毒性作用。细胞还有助于细胞存活、细胞迁移和增殖。_{为了评估机械性能，对 PVA/BC/gC 3}进行了拉伸强度测试N ₄ /nettles/trachyspermum纳米纤维，结果表明纳米复合材料具有良好的强度。此外，在体内试验中，生产的纳米纤维用于评估伤口愈合，结果表明这些纳米纤维能够加速伤口愈合过程，14天后，伤口愈合率为95%。因此，本研究表明，PVA/BC/gC ₃ N ₄ /nettles/trachyspermum纳米纤维有效抑制细菌生长，加速伤口愈合。