A naringin-containing soft contact lens (NCSC) was prepared as an antibacterial platform for long-term wearable soft contact lens. The NCSC showed sustained release of naringin for about a period of 1 month without changing the surface morphology. The effluent solution from NCSC exhibited very low cytotoxicity and high antibacterial activities against Pseudomonas aeruginosa and Escherichia coli. In the intraocular eye drop experiments of effluent solution from NCSC, it had no difference with the control group and showed unstimulated status without any cell damage or side effect. The NCSC showed smoother surface with reduced contamination by P. aeruginosa after wearing of 3 consecutive weeks whereas the control soft contact lens showed extremely high contamination, indicating the effective antibacterial effect of NCSC upon extended wearing.

中文翻译：

---

含柚皮苷的软性隐形眼镜的抗菌作用

制备了一种含柚皮苷的软性隐形眼镜（NCSC）作为长期佩戴型软性隐形眼镜的抗菌平台。NCSC 显示柚皮苷持续释放约 1 个月，而不会改变表面形态。来自NCSC的流出液对铜绿假单胞菌和大肠杆菌表现出非常低的细胞毒性和高抗菌活性。在NCSC流出液眼内滴眼液实验中，与对照组无差异，呈未受刺激状态，无任何细胞损伤或副作用。NCSC 显示出更光滑的表面，减少了铜绿假单胞菌的污染 连续佩戴 3 周后，对照软性隐形眼镜表现出极高的污染，表明 NCSC 在长时间佩戴后具有有效的抗菌作用。