Cell-autonomous, tissue-specific circadian rhythms in gene expression and cellular processes have been observed throughout the human body. Disruption of daily rhythms by mistimed exposure to light, food intake, or genetic mutation has been linked to cancer development. Some medications are also more effective at certain times of day. However, a limited number of clinical studies have examined daily rhythms in the patient or drug timing as treatment strategies. This review highlights advances and challenges in cancer biology as a function of time of day. Recent evidence for daily rhythms and their entrainment in tumors indicate that personalized medicine should include understanding and accounting for daily rhythms in cancer patients.

已在整个人体中观察到基因表达和细胞过程中的细胞自主、组织特异性昼夜节律。因不合时宜的光照、食物摄入或基因突变而破坏日常节奏与癌症发展有关。一些药物在一天中的某些时间也更有效。然而，有限数量的临床研究已经检查了患者的每日节律或药物时间作为治疗策略。这篇综述强调了癌症生物学作为一天中时间的函数的进展和挑战。最近关于每日节律及其在肿瘤中的夹带的证据表明，个性化医疗应包括理解和解释癌症患者的每日节律。