ABSTRACT

Objective

To explore the clinicopathologic and prognostic significance of circular RNA plasmacytoma variant translocation 1 (circPVT1) in various cancers.

Methods

Several databases were searched for eligible studies published before March 01, 2021. The pooled odds ratios (ORs) with 95% confidence interval (95% CI) were calculated to assess the association between circPVT1 expression and prognostic outcomes of tumor including age, gender, clinical stage, tumor size, metastasis and overall survival. Begg’s funnel plots and Egger’s test were used to evaluate the publication bias. The robustness of our results was assessed using sensitivity analysis.

Results

Ten studies comprising a total of 878 patients with cancer were included in this meta-analysis. The results showed that the high expression of circPVT1 was significantly related to clinical stage (OR=3.44, 95% CI: 2.40-4.94, P<0.05), tumor size (OR=2.29, 95% CI: 1.38-3.79, P<0.05), metastasis (OR=2.97, 95% CI: 2.06-4.28, p<0.05) and overall survival of cancer (OR=3.30, 95% CI: 2.26-4.84, p<0.05), but not associated with age and gender of patients with tumor. No publication bias was found.

Conclusions

High expression of circPVT1 may predict an advanced clinical stage and poor prognosis of tumor, suggesting that circPVT1 may serve as a potential prognostic marker in cancers. 

中文翻译：

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环状RNA浆细胞瘤变异易位1在各种癌症中的临床病理学和预后作用

摘要

客观的

探讨环状 RNA 浆细胞瘤变异易位 1 (circPVT1) 在各种癌症中的临床病理学和预后意义。

方法

在几个数据库中搜索了 2021 年 3 月 1 日之前发表的符合条件的研究。计算具有 95% 置信区间 (95% CI) 的汇总优势比 (OR) 以评估 circPVT1 表达与肿瘤预后结果之间的关联，包括年龄、性别、临床分期、肿瘤大小、转移和总生存期。Begg 漏斗图和 Egger 检验用于评估发表偏倚。使用敏感性分析评估我们结果的稳健性。

结果

这项荟萃分析包括 10 项研究，共 878 名癌症患者。结果显示circPVT1高表达与临床分期（OR=3.44, 95% CI: 2.40-4.94, P<0.05）、肿瘤大小（OR=2.29, 95% CI: 1.38-3.79, P< 0.05)、转移 (OR=2.97, 95% CI: 2.06-4.28, p<0.05) 和癌症总生存期 (OR=3.30, 95% CI: 2.26-4.84, p<0.05)，但与年龄和肿瘤患者的性别。未发现发表偏倚。

结论

circPVT1的高表达可以预测肿瘤的晚期临床分期和不良预后，表明circPVT1可能作为癌症的潜在预后标志物。