Transcriptome profiling of five brain regions in a 6-hydroxydopamine rat model of Parkinson’s disease,CNS Neuroscience & Therapeutics

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Transcriptome profiling of five brain regions in a 6-hydroxydopamine rat model of Parkinson’s disease
CNS Neuroscience & Therapeutics ( IF 5.5 ) Pub Date : 2021-08-04 , DOI: 10.1111/cns.13702
Ying Lyu _{1,

2,

3} , Yiying Huang _{1,

2} , Guiying Shi _{1,

2} , Xuepei Lei _{1,

2} , Keya Li _{1,

2} , Ran Zhou ₄ , Lin Bai _{1,

2} , Chuan Qin _{1,

2}

Affiliation

Parkinson's disease (PD) is a neurodegenerative disease, and its pathogenesis is unclear. Previous studies mainly focus on the lesions of substantia nigra (SN) and striatum (Str) in PD. However, lesions are not limited. The olfactory bulb (OB), subventricular zone (SVZ), and hippocampus (Hippo) are also affected in PD.

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