In the past decades, many materials have been studied as carriers for targeted drug delivery. However, there is a need for utilizable and selective carrier materials with few side effects. Here, the magnetic Ganoderma Lucidum Spores (mGLS) as a highly efficient targeted drug delivery carrier were explored. Then the regulatable targeted drug delivery system was verified by loading and releasing of the 5-Fluorouracil (5-FU). The results showed that the maximum of the loaded 5-FU reached 250.23 mg·g⁻¹ in the mGLS. The cumulative release of the 5-FU for the drug delivery system could reach 80.11% and 67.14% in the PBS and HCl after 48 h, respectively. In addition, this system showed the good pharmacokinetic properties in vivo. After 12 h, the blood concentration in the 5-FU@mGLS group kept at 5.3 µg·mL⁻¹ and was four times higher than that in the 5-FU group. In summary, the GLS as a natural microscale core-shell structures appears the striking application in carrier material for oral drug delivery.

在过去的几十年中，已经研究了许多材料作为靶向药物递送的载体。然而，需要具有很少副作用的可利用且选择性的载体材料。在这里，探索了磁性灵芝孢子 (mGLS) 作为一种高效的靶向药物递送载体。然后通过加载和释放 5-氟尿嘧啶 (5-FU) 来验证可调节的靶向药物递送系统。结果表明，负载的5-FU在mGLS中的最大值达到250.23 mg·g ^-1。48 小时后，药物递送系统的 5-FU 在 PBS 和 HCl 中的累积释放量分别达到 80.11% 和 67.14%。此外，该系统在体内显示出良好的药代动力学特性。. 12小时后，5-FU@mGLS组的血药浓度保持在5.3 µg·mL ^-1，是5-FU组的4倍。总之，GLS作为一种天然的微尺度核壳结构在口服给药的载体材料中出现了惊人的应用。