The aim of this study was to reconstruct surface porous structure with hundreds of micrometers and then bio-mineralize Sr-doped Calcium Phosphate (Sr-doped CaP) on Polyetheretherketone (PEEK) profile to enhance its bioactivity. A surface porous structure was prepared on PEEK profile by embedding and acid-etching of SiO₂ particles as porogen (SP-PEEK). Then the Sr-doped CaP was further decorated on the porous surface after sulfonation, introduction of Sr-doped CaP crystal seeds and bio-mineralization in 1.5 times simulated body fluid (BSSP-PEEK-CaP/Sr). It was feasible to reconstruct the surface porous structure with hundreds of micrometers on PEEK profile by the present method without damaging its mechanical properties. The Sr-doped CaP crystal seeds effectively promoted the bio-mineralization of bio-inertness PEEK. All as-prepared PEEK did not inhibit the proliferation of cells. ALP of bio-mineralized groups was significantly increased than that of the other groups. The BSSP-PEEK-CaP/Sr obviously affected the morphology and promoted the adhesion and spreading of cells. As a result, the cyto-biocompatibity and bioactivity of PEEK were improved after bio-mineralization. Sr-doped CaP on PEEK most likely was beneficial for cells, which was associated with the increasing of the hydrophilicity on PEEK. This study provided a candidate method to improve the osteogenesis of PEEK implants.

本研究的目的是重建数百微米的表面多孔结构，然后在聚醚醚酮 (PEEK) 剖面上生物矿化掺 Sr 的磷酸钙（掺 Sr 的 CaP）以增强其生物活性。通过嵌入和酸蚀SiO ₂在PEEK轮廓上制备表面多孔结构颗粒作为致孔剂 (SP-PEEK)。然后在磺化、引入Sr掺杂的CaP晶种和在1.5倍模拟体液(BSSP-​​PEEK-CaP/Sr)中生物矿化后，将掺杂Sr的CaP进一步装饰在多孔表面上。通过本方法在不破坏其机械性能的情况下重建 PEEK 轮廓上数百微米的表面多孔结构是可行的。Sr掺杂的CaP晶种有效地促进了生物惰性PEEK的生物矿化。所有制备的 PEEK 均不抑制细胞增殖。生物矿化组的ALP显着高于其他组。BSSP-​​PEEK-CaP/Sr明显影响细胞的形态并促进细胞的粘附和扩散。因此，生物矿化后PEEK的细胞生物相容性和生物活性得到提高。PEEK 上掺杂 Sr 的 CaP 最有可能对细胞有益，这与 PEEK 上亲水性的增加有关。该研究为改善 PEEK 植入物的成骨提供了一种候选方法。