Therapeutic contact lenses for ocular drug delivery have received considerable interest as they can potentially enhance ocular bioavailability, increase patient compliance, and reduce side effects. Along with the successful in vitro and in vivo studies on sustained drug delivery through contact lenses, lens critical properties such as water content, optical transparency and modulus have also been investigated. Aside from issues such as drug stability or burst release, the potential for the commercialization of pharmaceutical-loaded lenses can be limited by the alteration of lens physical and chemical properties upon the incorporation of therapeutic or non-therapeutic components.

This review outlines advances in the use of pharmaceutical-loaded contact lenses and their relevant characterization methodologies as a potential ocular drug delivery system from 2010 to 2020, while summarizing current gaps and challenges in this field. A key reference point for this review is the relevant ISO standards on contact lenses, relating to the associated characterization methodologies. The content of this review is categorized based on the chemical, physical and mechanical properties of the loaded lens with the shortcomings of such analytical technologies examined.

用于眼部药物输送的治疗性隐形眼镜引起了极大的兴趣，因为它们可以潜在地提高眼部生物利用度、增加患者依从性并减少副作用。除了通过隐形眼镜持续给药的体外和体内研究取得成功外，还研究了镜片的关键特性，例如含水量、光学透明度和模量。除了药物稳定性或爆发性释放等问题外，载药镜片的商业化潜力可能会因加入治疗性或非治疗性成分后镜片物理和化学性质的改变而受到限制。

本综述概述了 2010 年至 2020 年使用载药隐形眼镜及其相关表征方法作为潜在眼部给药系统的进展，同时总结了该领域当前的差距和挑战。本次审查的一个关键参考点是隐形眼镜的相关 ISO 标准，与相关的表征方法有关。本综述的内容是根据装载镜片的化学、物理和机械性能进行分类的，并检查了此类分析技术的缺点。