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Accelerated COVID-19 vaccine development: milestones, lessons, and prospects
Immunity ( IF 32.4 ) Pub Date : 2021-08-03 , DOI: 10.1016/j.immuni.2021.07.017
Karin Bok 1 , Sandra Sitar 1 , Barney S Graham 1 , John R Mascola 1
Affiliation  

The development of effective vaccines to combat infectious diseases is a complex multi-year and multi-stakeholder process. To accelerate the development of vaccines for coronavirus disease 2019 (COVID-19), a novel pathogen emerging in late 2019 and spreading globally by early 2020, the United States government (USG) mounted an operation bridging public and private sector expertise and infrastructure. The success of the endeavor can be seen in the rapid advanced development of multiple vaccine candidates, with several demonstrating efficacy and now being administered around the globe. Here, we review the milestones enabling the USG-led effort, the methods utilized, and ensuing outcomes. We discuss the current status of COVID-19 vaccine development and provide a perspective for how partnership and preparedness can be better utilized in response to future public-health pandemic emergencies.



中文翻译:

加速 COVID-19 疫苗开发:里程碑、教训和前景

开发有效的疫苗来对抗传染病是一个复杂的多年和多利益相关者的过程。2019 年冠状病毒病 (COVID-19) 是一种于 2019 年底出现并于 2020 年初在全球传播的新型病原体,为了加速其疫苗的开发,美国政府 (USG) 开展了一项旨在连接公共和私营部门专业知识和基础设施的行动。这一努力的成功可以从多种候选疫苗的快速先进开发中看出,其中几种疫苗已证明有效,目前正在全球范围内使用。在这里,我们回顾了美国政府领导的努力的里程碑、所使用的方法以及随后的成果。我们讨论了 COVID-19 疫苗开发的现状,并为如何更好地利用伙伴关系和准备工作来应对未来的公共卫生大流行紧急情况提供了展望。

更新日期:2021-08-10
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