Fibroblastic reticular cells (FRCs) are a crucial part of the stromal cell infrastructure of secondary lymphoid organs (SLOs). Lymphoid organ fibroblasts form specialized niches for immune cell interactions and thereby govern lymphocyte activation and differentiation. Moreover, FRCs produce and ensheath a network of extracellular matrix (ECM) microfibers called the conduit system. FRC-generated conduits contribute to fluid and immune cell control by funneling fluids containing antigens and inflammatory mediators through the SLOs. We review recent progress in FRC biology that has advanced our understanding of immune cell functions and interactions. We discuss the intricate relationships between the cellular FRC and the fibrillar conduit networks, which together form the basis for efficient communication between immune cells and the tissues they survey.

成纤维细胞网状细胞 (FRC) 是次级淋巴器官 (SLO) 基质细胞基础结构的重要组成部分。淋巴器官成纤维细胞为免疫细胞相互作用形成专门的生态位，从而控制淋巴细胞的活化和分化。此外，FRC 产生并包裹着称为导管系统的细胞外基质 (ECM) 微纤维网络。FRC 生成的管道通过 SLO 汇集含有抗原和炎症介质的液体，从而有助于液体和免疫细胞控制。我们回顾了 FRC 生物学的最新进展，这些进展促进了我们对免疫细胞功能和相互作用的理解。我们讨论了蜂窝 FRC 和纤维导管网络之间的复杂关系，