Diagnostic work-up for severe aplastic anemia in children: Consensus of the North American Pediatric Aplastic Anemia Consortium,American Journal of Hematology

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Diagnostic work-up for severe aplastic anemia in children: Consensus of the North American Pediatric Aplastic Anemia Consortium
American Journal of Hematology ( IF 12.8 ) Pub Date : 2021-08-03 , DOI: 10.1002/ajh.26310
Kristin A Shimano ₁ , Anupama Narla ₂ , Melissa J Rose ₃ , Nicholas J Gloude ₄ , Steven W Allen ₅ , Katie Bergstrom ₆ , Larisa Broglie ₇ , Beth A Carella ₈ , Paul Castillo ₉ , Jill L O de Jong ₁₀ , Yigal Dror ₁₁ , Amy E Geddis ₆ , James N Huang ₁ , Bonnie W Lau ₁₂ , Catherine McGuinn ₁₃ , Taizo A Nakano ₁₄ , Kathleen Overholt ₁₅ , Jennifer A Rothman ₁₆ , Anjali Sharathkumar ₁₇ , Evan Shereck ₁₈ , Adrianna Vlachos ₁₉ , Timothy S Olson ₂₀ , Alison A Bertuch ₂₁ , Marcin W Wlodarski ₂₂ , Akiko Shimamura ₂₃ , Jessica Boklan ₂₄

Affiliation

Department of Pediatrics, University of California San Francisco Benioff Children's Hospital, San Francisco, California, USA.
Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Division of Hematology, Oncology, and Bone Marrow Transplant, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Department of Pediatrics, University of California San Diego, Rady Children's Hospital, San Diego, California, USA.
Pediatric Hematology/Oncology, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Cancer and Blood Disorders Center, Seattle Children's Hospital, Seattle, Washington, USA.
Department of Pediatric Hematology, Oncology, Blood and Marrow Transplantation, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Department of Pediatrics, Kaiser Permanente, Washington, District of Columbia, USA.
Division of Pediatric Hematology Oncology, UF Health Shands Children's Hospital, Gainesville, Florida, USA.
Section of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, Illinois, USA.
Marrow Failure and Myelodysplasia Program, Division of Hematology and Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
Pediatric Hematology-Oncology, Dartmouth-Hitchcock, Lebanon, New Hampshire, USA.
Department of Pediatrics, Weill Cornell Medicine, New York, New York, USA.
Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, Colorado, USA.
Pediatric Hematology and Oncology, Riley Hospital for Children at Indiana University, Indianapolis, Indiana, USA.
Division of Pediatric Hematology and Oncology, Duke University Medical Center, Durham, North Carolina, USA.
Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA.
Hematology, Oncology and Cellular Therapy, Cohen Children's Medical Center, New Hyde Park, New York, USA.
Cell Therapy and Transplant Section, Division of Oncology and Bone Marrow Failure, Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Department of Hematology, St. Jude Children's Hospital, Memphis, Tennessee, USA.
Cancer and Blood Disorders Center, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA.
Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona, USA.

The North American Pediatric Aplastic Anemia Consortium (NAPAAC) is a group of pediatric hematologist-oncologists, hematopathologists, and bone marrow transplant physicians from 46 institutions in North America with interest and expertise in aplastic anemia, inherited bone marrow failure syndromes, and myelodysplastic syndromes. The NAPAAC Bone Marrow Failure Diagnosis and Care Guidelines Working Group was established with the charge of harmonizing the approach to the diagnostic workup of aplastic anemia in an effort to standardize best practices in the field. This document outlines the rationale for initial evaluations in pediatric patients presenting with signs and symptoms concerning for severe aplastic anemia.

中文翻译：

儿童严重再生障碍性贫血的诊断检查：北美小儿再生障碍性贫血联盟的共识

北美小儿再生障碍性贫血联盟 (NAPAAC) 是一个由来自北美 46 家机构的小儿血液肿瘤学家、血液病理学家和骨髓移植医生组成的团体，他们对再生障碍性贫血、遗传性骨髓衰竭综合征和骨髓增生异常综合征感兴趣并具有专业知识。NAPAAC 骨髓衰竭诊断和护理指南工作组的成立负责协调再生障碍性贫血的诊断检查方法，以努力标准化该领域的最佳实践。本文件概述了对出现与严重再生障碍性贫血相关的体征和症状的儿科患者进行初步评估的基本原理。

更新日期：2021-10-12

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