Biofouling on medical device surfaces, which is initiated by protein adsorption and adhesion of microbes especially the antibiotic-resistant bacteria, attracts global attention for centuries due to its enduring challenges in healthcare. Here, the antifouling effect of hydrophilic poly(glycerol glycidyl ether) (polyGGE) film is explored in comparison to hemocompatible and protein-resistant control polymers. The chemical and thermomechanical stability of polyGGE in hydrated conditions at body temperature was achieved via adjusting UV curing and KOH quenching time. The polyGGE surface is inert to the plasma protein adsorption and interfered the metabolism conditions, biofilm formation and growth of both Gram negative (Gram–) and antibiotic-resistant Gram positive (Gram+) bacteria. These results indicate the potential application of polyGGE for combating the risk of hospital-acquired infections and preventing drug-resistant superbug spreading.

中文翻译：

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用抗蛋白质的polyGGE薄膜击败抗生素抗性细菌

医疗器械表面的生物污染是由蛋白质吸附和微生物（尤其是耐抗生素细菌）的粘附引起的，由于其在医疗保健领域的持久挑战，几个世纪以来一直受到全球关注。在这里，与血液相容性和抗蛋白质对照聚合物相比，探索了亲水性聚（甘油缩水甘油醚）（polyGGE）薄膜的防污效果。polyGGE 在体温水合条件下的化学和热机械稳定性是通过调节 UV 固化和 KOH 淬灭时间来实现的。polyGGE 表面对血浆蛋白吸附呈惰性，并会干扰革兰氏阴性 (Gram-) 和耐药革兰氏阳性 (Gram+) 细菌的代谢条件、生物膜形成和生长。