Murine Irgm paralogs regulate non-redundant functions to execute host defense to Toxoplasma gondii,Infection and Immunity

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Murine Irgm paralogs regulate non-redundant functions to execute host defense to Toxoplasma gondii
Infection and Immunity ( IF 3.1 ) Pub Date : 2021-08-02 , DOI: 10.1128/iai.00202-21
Jacob Dockterman ₁ , Brian E Fee _{2,

3} , Gregory A Taylor _{1,

2,

3,

4} , Jörn Coers _{1,

4}

Affiliation

Gamma-interferon (IFNγ)-induced immunity-related GTPases (IRGs) confer cell-autonomous immunity to the intracellular protozoan pathogen Toxoplasma gondii. Effector IRGs are loaded onto the Toxoplasma-containing parasitophorous vacuole (PV), where they ...

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