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What is paradoxical lucidity? The answer begins with its definition
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2021-08-02 , DOI: 10.1002/alz.12424
Andrew Peterson 1, 2 , Justin Clapp 1, 3, 4 , Emily A Largent 1, 4 , Kristin Harkins 1 , Shana D Stites 1, 5 , Jason Karlawish 1, 4
Affiliation  

Paradoxical lucidity in dementia is a clinically significant but understudied phenomenon. A provisional definition was proposed by the 2018 National Institute on Aging expert workshop and published in Alzheimer's and Dementia. However, several conceptual features of this definition remain vague, creating barriers to robust clinical research. Here, we critically analyze the provisional definition and present a refined definition that can be applied in clinical research. The refined definition is based on an analytic process our research group recently undertook to operationalize paradoxical lucidity for our own study protocol. Our goal is to facilitate debate and potentially harmonize interpretations of paradoxical lucidity among research groups.

中文翻译:

什么是似是而非的清醒?答案从它的定义开始

痴呆症中矛盾的清醒是一种具有临床意义但未被充分研究的现象。2018 年国家衰老研究所专家研讨会提出了一个临时定义,并发表在阿尔茨海默氏症和痴呆症上。然而,这个定义的几个概念特征仍然含糊不清,为稳健的临床研究制造了障碍。在这里,我们批判性地分析了临时定义,并提出了一个可以应用于临床研究的细化定义。精炼的定义是基于我们的研究小组最近为我们自己的研究方案实施自相矛盾的清晰度而进行的分析过程。我们的目标是促进辩论,并可能协调研究小组之间对似是而非的清晰度的解释。
更新日期:2021-08-02
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