Plants are resistant to most pathogens because of an immune system that perceives invading microbes and activates defense. A large repertoire of innate immune receptors mediates specific direct or indirect recognition of pathogen-derived molecules. Disease is often a consequence of insufficient immune surveillance, and the transfer of immune receptor genes from resistant plants to susceptible crop varieties is an effective strategy for combating disease outbreaks. We discuss approaches for identifying intracellular and cell surface immune receptors, with particular focus on recently developed and emerging methodologies. We also review considerations for the transfer of immune receptor genes into crop species, including additional host factors that may be required for immune receptor function. Together, these concepts lay out a broadly applicable playbook for developing crop varieties with durable disease resistance.

中文翻译：

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通过免疫受体识别和转移开发抗病作物的手册。

由于免疫系统能够感知入侵的微生物并激活防御，植物对大多数病原体具有抗性。大量先天免疫受体介导病原体衍生分子的特异性直接或间接识别。疾病通常是免疫监视不足的结果，将免疫受体基因从抗性植物转移到易感作物品种是对抗疾病爆发的有效策略。我们讨论了识别细胞内和细胞表面免疫受体的方法，特别关注最近开发的和新兴的方法。我们还回顾了将免疫受体基因转移到作物物种中的考虑因素，包括免疫受体功能可能需要的其他宿主因素。一起，