Weaning stress can elicit changes in the metabolic, hormone and immune systems of pigs and interact with prolonged disruptions stemming from maternal immune activation (MIA) during gestation. The present study advances the characterization of the combined effects of weaning stress and MIA on blood chemistry, immune and hormone indicators that inform on the health of pigs. Three-week-old female and male offspring of control gilts or gilts infected with the porcine reproductive and respiratory syndrome virus were allocated to weaned or nursed groups. The anion gap and bilirubin profiles suggest that MIA enhances tolerance to the effects of weaning stress. Interleukin 1 beta and interleukin 2 were highest among weaned MIA females, and cortisol was higher among weaned relative to nursed pigs across sexes. Canonical discriminant analysis demonstrated that weaned and nursed pigs have distinct chemistry profiles, whereas MIA and control pigs have distinct cytokine profiles. The results from this study can guide management practices that recognize the effects of the interaction between MIA and weaning stress on the performance and health of pigs.

中文翻译：

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猪妊娠期断奶应激和免疫激活对血清细胞因子和分析物浓度的综合影响

断奶压力会引起猪的代谢、激素和免疫系统的变化，并与妊娠期间母体免疫激活 (MIA) 引起的长时间中断相互作用。本研究推进了断奶应激和 MIA 对影响猪健康的血液化学、免疫和激素指标的综合影响的表征。对照后备母猪或感染猪繁殖与呼吸综合征病毒的后备母猪的三周龄雌性和雄性后代被分配到断奶组或哺乳组。阴离子间隙和胆红素谱表明 MIA 增强了对断奶应激影响的耐受性。白细胞介素 1 β 和白细胞介素 2 在断奶的 MIA 母猪中最高，而在断奶的母猪中皮质醇含量高于所有性别的哺乳猪。典型判别分析表明，断奶猪和哺乳猪具有不同的化学特征，而 MIA 和对照猪具有不同的细胞因子特征。这项研究的结果可以指导管理实践，以识别 MIA 和断奶应激之间的相互作用对猪的生产性能和健康的影响。