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SPM Receptor Expression and Localization in Irradiated Salivary Glands
Journal of Histochemistry & Cytochemistry ( IF 3.2 ) Pub Date : 2021-08-02 , DOI: 10.1369/00221554211031678
Harim Tavares Dos Santos 1 , Kihoon Nam 1 , Jason P Hunt 2 , Luke O Buchmann 2 , Marcus M Monroe 2 , Olga J Baker 1, 3
Affiliation  

Radiation therapy–mediated salivary gland destruction is characterized by increased inflammatory cell infiltration and fibrosis, both of which ultimately lead to salivary gland hypofunction. However, current treatments (e.g., artificial saliva and sialagogues) only promote temporary relief of symptoms. As such, developing alternative measures against radiation damage is critical for restoring salivary gland structure and function. One promising option for managing radiation therapy–mediated damage in salivary glands is by activation of specialized proresolving lipid mediator receptors due to their demonstrated role in resolution of inflammation and fibrosis in many tissues. Nonetheless, little is known about the presence and function of these receptors in healthy and/or irradiated salivary glands. Therefore, the goal of this study was to detect whether these specialized proresolving lipid mediator receptors are expressed in healthy salivary glands and, if so, if they are maintained after radiation therapy–mediated damage. Our results indicate that specialized proresolving lipid mediator receptors are heterogeneously expressed in inflammatory as well as in acinar and ductal cells within human submandibular glands and that their expression persists after radiation therapy. These findings suggest that epithelial cells as well as resident immune cells represent potential targets for modulation of resolution of inflammation and fibrosis in irradiated salivary glands.



中文翻译:

SPM 受体在辐照唾液腺中的表达和定位

放射治疗介导的唾液腺破坏以炎症细胞浸润和纤维化增加为特征,这两者最终都会导致唾液腺功能减退。然而,目前的治疗方法(例如,人工唾液和唾液酸剂)只能促进症状的暂时缓解。因此,开发针对辐射损伤的替代措施对于恢复唾液腺结构和功能至关重要。管理放射治疗介导的唾液腺损伤的一种有希望的选择是通过激活专门的促分解脂质介质受体,因为它们在许多组织中的炎症和纤维化消退中已被证明具有作用。尽管如此,关于这些受体在健康和/或辐照唾液腺中的存在和功能知之甚少。所以,这项研究的目的是检测这些专门的促分解脂质介质受体是否在健康的唾液腺中表达,如果是,它们是否在放射治疗介导的损伤后仍然存在。我们的研究结果表明,专门的促分解脂质介质受体在人类颌下腺内的炎症细胞以及腺泡和导管细胞中异质表达,并且它们的表达在放射治疗后持续存在。这些发现表明,上皮细胞和常驻免疫细胞代表了调节受辐射唾液腺炎症和纤维化消退的潜在靶标。我们的研究结果表明,专门的促分解脂质介质受体在人类颌下腺内的炎症细胞以及腺泡和导管细胞中异质表达,并且它们的表达在放射治疗后持续存在。这些发现表明,上皮细胞和常驻免疫细胞代表了调节受辐射唾液腺炎症和纤维化消退的潜在靶标。我们的研究结果表明,专门的促分解脂质介质受体在人类颌下腺内的炎症细胞以及腺泡和导管细胞中异质表达,并且它们的表达在放射治疗后持续存在。这些发现表明,上皮细胞和常驻免疫细胞代表了调节受辐射唾液腺炎症和纤维化消退的潜在靶标。

更新日期:2021-08-02
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