Context

Persons with spinal cord injury (SCI) present with low fat oxidation that is associated with poor cardiometabolic health. This study compared changes in fat and carbohydrate (CHO) oxidation during moderate intensity continuous exercise in persons with SCI and able-bodied adults (AB).

Design

Repeated measures, within-subjects study.

Setting

University laboratory in San Diego, CA.

Participants

Nine men and women with SCI (age and time since injury = 32 ± 11 yr and 7 ± 6 yr) and 10 AB adults (age = 25 ± 8 yr).

Interventions

To assess peak oxygen uptake (VO₂peak) and peak power output (PPO), participants performed progressive arm ergometry to volitional exhaustion. Subsequently, they completed 25 min of continuous exercise at 45%PPO.

Outcome Measures

Respiratory exchange ratio (RER), fat and CHO oxidation, and blood lactate concentration (BLa) were assessed.

Results

Data showed a similar RER (P = 0.98) during exercise in SCI (0.97 ± 0.04) versus AB (0.97 ± 0.03) reflecting high CHO use and no differences in BLa (3.5 ± 1.1 and 3.0 ± 0.9 vs. mM, P = 0.56) or fat and CHO oxidation between groups (P > 0.05). However, participants with SCI exercised at a higher relative intensity (P < 0.01, 84 ± 7 vs. 75 ± 7%HRpeak) versus AB.

Conclusion

Data confirm high reliance on CHO during arm ergometry in persons with SCI. To better compare substrate utilization to AB adults, we recommend that exercise be prescribed according to peak heart rate due to differences in cardiorespiratory fitness between groups.

中文翻译：

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脊髓损伤患者与健全人对手臂自行车运动的反应相似的脂肪和碳水化合物氧化

语境

脊髓损伤 (SCI) 患者存在与心脏代谢健康不良相关的低脂肪氧化。本研究比较了 SCI 患者和身体健全的成年人 (AB) 在中等强度连续运动期间脂肪和碳水化合物 (CHO) 氧化的变化。

设计

重复测量，受试者内研究。

环境

加利福尼亚州圣地亚哥的大学实验室。

参加者

9 名患有 SCI 的男性和女性（受伤后的年龄和时间 = 32 ± 11 岁和 7 ± 6 岁）和 10 名 AB 成人（年龄 = 25 ± 8 岁）。

干预措施

为评估峰值摄氧量（VO ₂峰值）和峰值功率输出 (PPO)，参与者进行了渐进式手臂测力法直至意志力竭。随后，他们以 45%PPO 完成了 25 分钟的连续运动。

结果措施

评估了呼吸交换率 (RER)、脂肪和 CHO 氧化以及血乳酸浓度 (BLa)。

结果

数据显示 SCI (0.97 ± 0.04) 与 AB (0.97 ± 0.03) 运动期间的 RER 相似 ( P  = 0.98)，反映出高 CHO 使用率且 BLa 无差异（3.5 ± 1.1 和 3.0 ± 0.9 与 mM，P  = 0.56 ) 或组间脂肪和 CHO 氧化 ( P  > 0.05)。然而，与 AB 相比，SCI 参与者以更高的相对强度（P  < 0.01，84 ± 7 对比 75 ± 7%HRpeak）进行锻炼。

结论

数据证实在 SCI 患者的手臂测功期间高度依赖 CHO。为了更好地比较 AB 成人的底物利用率，我们建议根据峰值心率进行锻炼，因为各组之间的心肺健康存在差异。