Objective. Peritoneal adhesion (PA) is an abnormal connective tissue that usually occurs between tissues adjacent to damaged organs during processes such as surgery. In this study, the anti-inflammatory and antioxidant effects of Portulaca oleracea (PO) were investigated against postoperative-induced peritoneal adhesion. Methods. Thirty healthy male Wistar rats (, 6-8 weeks) were randomly divided into four groups: (1) normal, (2) control (induced peritoneal adhesion), and (3) and (4) PO extracts (induced peritoneal adhesion and received 100 or 300 mg/kg/day of PO extract for seven days). Finally, macroscopic and microscopic examinations were performed using different scoring systems and immunoassays in the peritoneal lavage fluid. Results. We found that the levels of adhesion scores and interleukin- (IL-) 1β, IL-6, IL-10, tumour necrosis factor- (TNF-) α, transforming growth factor- (TGF-) β₁, vascular endothelial growth factor (VEGF), and malondialdehyde (MDA) were increased in the control group. However, PO extract (100 and 300 mg/kg) notably reduced inflammatory (IL-1β, IL-6, and TNF-α), fibrosis (TGF-β₁), angiogenesis (VEGF), and oxidative (MDA) factors, while increased anti-inflammatory cytokine IL-10, antioxidant factor glutathione (GSH), compared to the control group. Conclusion. Oral administration of PO improved postoperational-induced PA by alleviating the oxidative factors, fibrosis, inflammatory cytokines, angiogenesis biomarkers, and stimulating antioxidative factors. Hence, PO can be considered a potential herbal medicine to manage postoperative PA. However, further clinical studies are required to approve the effectiveness of PO.

中文翻译：

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马齿苋乙醇提取物对手术性腹膜粘连的治疗效果评价

客观。腹膜粘连 (PA) 是一种异常的结缔组织，通常在手术等过程中发生在与受损器官相邻的组织之间。在这项研究中，研究了马齿苋(PO) 对术后诱导的腹膜粘连的抗炎和抗氧化作用。方法。30 只健康雄性 Wistar 大鼠 (, 6-8 周) 被随机分为四组: (1) 正常, (2) 对照(诱导腹膜粘连), (3) 和 (4) PO 提取物(诱导腹膜粘连并接受 100 或 300 mg/kg /day PO 提取 7 天）。最后，在腹腔灌洗液中使用不同的评分系统和免疫测定进行宏观和微观检查。结果。我们发现黏附评分水平与白细胞介素-（IL-） 1β、IL-6、IL-10、肿瘤坏死因子-（TNF-） α、转化生长因子-（TGF-_）β1、血管内皮生长因子（VEGF）和丙二醛（MDA）在对照组中增加。然而，PO 提取物（100 和 300 mg/kg）显着降低炎症（IL-1 β、IL-6 和 TNF- α）、纤维化（TGF- β1 _）、血管生成（VEGF）和氧化（MDA）因子，而与对照组相比，抗炎细胞因子 IL-10、抗氧化因子谷胱甘肽 (GSH) 增加。结论. 口服 PO 通过减轻氧化因子、纤维化、炎性细胞因子、血管生成生物标志物和刺激抗氧化因子来改善术后诱导的 PA。因此，PO 可以被认为是管理术后 PA 的潜在草药。然而，需要进一步的临床研究来批准 PO 的有效性。