Lynch syndrome is the most common inherited cancer syndrome that increases the risk of developing colorectal and endometrial cancer. Universal screening guidelines were first recommended by the Centers for Disease Control and Prevention (CDC) in 2009 and are updated annually by multiple societies. Therefore, one would expect genetic testing rates to increase over time. But testing remains underutilized among those with colorectal or endometrial cancer, even though early detection can improve prognosis and survival rates. In this study, we aimed to understand differences in genetic testing uptake among those with colorectal cancer or endometrial cancer from 2005, 2010, 2015, using data from the National Health Interview Survey (NHIS). We examined genetic testing uptake across cancer-type, age (≤50 or ≥51), sex, race, insurance, and education using a χ2 statistical analysis. Despite an upward genetic testing trend in 2010, we found no significant differences in genetic testing uptake over time. In 2010, non-White individuals experienced the highest increase from 2005 in comparison with White individuals. However, genetic testing rates declined for both groups by 2015. Our findings show that genetic testing for colorectal cancer and endometrial cancer did not increase over a 10-year period in spite of guidelines that recommend testing. Prevention Relevance: Genetic testing uptake for colorectal cancer and endometrial cancer has not increased over a 10-year period in spite of universal screening guidelines. More genetic testing education is needed at the provider and patient level to improve screening strategies for cancer patients who are most at risk for Lynch syndrome.

中文翻译：

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全国健康访谈调查中林奇综合征风险癌症患者基因检测的采用情况

林奇综合征是最常见的遗传性癌症综合征，会增加患结直肠癌和子宫内膜癌的风险。通用筛查指南于 2009 年首次由疾病控制和预防中心 (CDC) 推荐，并由多个学会每年更新。因此，人们预计基因检测率会随着时间的推移而增加。但在结直肠癌或子宫内膜癌患者中，检测仍未得到充分利用，尽管早期检测可以改善预后和生存率。在这项研究中，我们旨在使用来自全国健康访谈调查 (NHIS) 的数据了解 2005 年、2010 年、2015 年结直肠癌或子宫内膜癌患者的基因检测摄取差异。我们检查了癌症类型、年龄（≤50 或 ≥51）、性别、种族、保险、和教育使用 χ2 统计分析。尽管 2010 年基因检测呈上升趋势，但我们发现随着时间的推移，基因检测的吸收没有显着差异。2010 年，与白人相比，非白人的增幅自 2005 年以来最高。然而，到 2015 年，两组的基因检测率都下降了。我们的研究结果表明，尽管有推荐检测的指南，但对结直肠癌和子宫内膜癌的基因检测在 10 年内并没有增加。预防相关性：尽管有普遍的筛查指南，但在过去 10 年中，对结直肠癌和子宫内膜癌的基因检测并没有增加。需要在提供者和患者层面进行更多的基因检测教育，以改进对林奇综合征风险最高的癌症患者的筛查策略。