Results in Chemistry Pub Date : 2021-08-02 , DOI: 10.1016/j.rechem.2021.100162 Sachin A. Deodware 1 , Umesh B. Barache 1 , Umakant B. Chanshetti 2 , D.J. Sathe 3 , Ubale Panchsheela Ashok 4, 5 , Shashikant H. Gaikwad 1 , Shiva Prasad Kollur 6
The new Schiff base ligands 4-(2′/3′/4′-nitrobenzelideneimino)-3-methyl/ethyl-5-mercapto-1,2,4-triazole and their Co(II) metal complexes were synthesized and characterized by elemental analysis, magnetic moment measurements, thermal studies, electronic absorption and NMR spectroscopy. The ligands were synthesized by condensation of 4-amino-5-mercapto-3-methyl/ethyl-1,2,4-triazole with 2/3/4-nitrobenzaldehyde. On the basis of electronic absorption spectral data and magnetic susceptibility measurements, the octahedral geometry has been proposed for all the Co(II) complexes. Further, the ligands and Co(II) complexes have been screened for their antimicrobial activities against bacteria (Staphylococcus aureus, Pseudomonas aeruginosa) and fungi (Aspergillus niger and Candida albicans). Furthermore, the synthesized compounds were also screened for anticancer activity on human cancer cell lines such as breast (MCF7), lung (NCI-H226), prostate (PC-3) and ovary (OVCAR-3) by sulforhodamine-B (SRB) colorimetric assay.
中文翻译:
新合成的基于三唑的席夫碱配体及其 Co(II) 配合物作为抗菌剂和抗癌剂:化学合成、结构和生物学研究
合成了新的席夫碱配体 4-(2'/3'/4'-nitrobenzelideneimino)-3-methyl/ethyl-5-mercapto-1,2,4-triazole 及其 Co(II) 金属配合物,并表征为元素分析、磁矩测量、热研究、电子吸收和核磁共振光谱。通过4-氨基-5-巯基-3-甲基/乙基-1,2,4-三唑与2/3/4-硝基苯甲醛缩合合成配体。在电子吸收光谱数据和磁化率测量的基础上,提出了所有 Co(II) 配合物的八面体几何结构。此外,还筛选了配体和 Co(II) 复合物对细菌(金黄色葡萄球菌、铜绿假单胞菌)和真菌(黑曲霉和白色念珠菌)。此外,还通过磺基罗丹明-B (SRB) 筛选合成的化合物对乳腺癌 (MCF7)、肺癌 (NCI-H226)、前列腺 (PC-3) 和卵巢 (OVCAR-3) 等人类癌细胞系的抗癌活性比色法。