Social anxiety disorder (SAD) is characterized by negative self-referential processing, which triggers excessive emotional reactivity. In healthy individuals, positive self-views typically predominate and are supported by regions of the default mode network (DMN) that represent self-related information and regions of the frontoparietal control network (FPCN) that contribute to metacognitive awareness and emotion regulation. The current study used functional magnetic resonance imaging (fMRI) to examine patterns of DMN and FPCN activation during positive and negative self-referential judgments in SAD patients (N = 97) and controls (N = 34). As expected, SAD patients demonstrated a striking difference in self-beliefs compared with non-anxious healthy controls, endorsing fewer positive traits and more negative traits. However, SAD patients and controls demonstrated largely similar patterns of DMN and FPCN recruitment during self-referential judgements. No significant group differences were observed. However, equivalence testing identified numerous regions demonstrating effect sizes that were not small enough to conclude that they were practically equivalent to zero, despite the nonsignificant null hypothesis test. These regions may be key targets to investigate in future studies using larger samples.

社交焦虑症（SAD）的特点是消极的自我参照处理，这会引发过度的情绪反应。在健康个体中，积极的自我观点通常占主导地位，并得到代表自我相关信息的默认模式网络 (DMN) 区域和有助于元认知意识和情绪调节的额顶控制网络 (FPCN) 区域的支持。目前的研究使用功能磁共振成像 (fMRI) 来检查 SAD 患者 ( N = 97) 和对照组 ( N= 34)。正如预期的那样，与不焦虑的健康对照组相比，SAD 患者的自信心表现出显着差异，支持更少的积极特征和更多的消极特征。然而，SAD 患者和对照组在自我参照判断过程中表现出大体相似的 DMN 和 FPCN 招募模式。未观察到显着的组间差异。然而，等价检验确定了许多区域，这些区域的效应大小不足以得出结论，尽管零假设检验不显着，但它们实际上等于零。这些区域可能是未来使用更大样本进行研究的关键目标。