Abstract

A consecutive synthesis of highly-functionalized spirocyclopentane derivatives via sequential reaction of ethyl 2,4-dioxo-arylbutanoates, malononitrile (or ethyl 2-cyanoacetate), and vicinal dicarbonyl compounds, such as ninhydrin, isatin, and acenaphthenequinone in MeCN at room temperature is described. The advantages of this protocol are short reaction time, simple procedure, and good yields.

中文翻译：

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由 2,4-二氧代-芳基丁酸酯、丙二腈和邻位二羰基化合物连续合成螺环戊烷

摘要

在室温下，通过 2,4-二氧代-芳基丁酸乙酯、丙二腈（或 2-氰基乙酸乙酯）和邻位二羰基化合物（如茚三酮、靛红和苊醌）在 MeCN 中的顺序反应连续合成高度官能化的螺环戊烷衍生物是描述。该协议的优点是反应时间短、程序简单、收率好。