Clinical management of patients with severe complications of COVID-19 has been hindered by a lack of effective drugs and a failure to capture the extensive heterogeneity of the disease with conventional methods. Here we review the emerging roles of complex organoids in the study of SARS-CoV-2 infection, modelling of COVID-19 disease pathology and in drug, antibody and vaccine development. We discuss opportunities for COVID-19 research and remaining challenges in the application of organoids.

中文翻译：

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研究 SARS-CoV-2 感染性和复杂类器官的治疗反应

由于缺乏有效的药物以及无法用传统方法捕捉该疾病的广泛异质性，对患有 COVID-19 严重并发症的患者的临床管理受到阻碍。在这里，我们回顾了复杂类器官在 SARS-CoV-2 感染研究、COVID-19 疾病病理学建模以及药物、抗体和疫苗开发中的新兴作用。我们讨论了 COVID-19 研究的机遇以及类器官应用中仍存在的挑战。