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Synthesis of highly swellable silver nanocomposite ionic double network (Ag-IDN) hydrogels and study of their characteristic properties
Polymer Bulletin ( IF 3.2 ) Pub Date : 2021-08-02 , DOI: 10.1007/s00289-021-03816-5
Nand Kumar 1 , Akansha Dixit 1 , Dibyendu S. Bag 1
Affiliation  

Nowadays, silver nanoparticle (AgNP)-embedded nanocomposite hydrogels are very attractive soft materials for biomedical applications. In this investigation, AgNPs were incorporated into ionic double network (IDN) hydrogels by in-situ reduction of AgNO3 using citric acid in the fully swollen hydrogels. The IDN hydrogels were pH-responsive multifunctional double network consisting of poly(vinyl alcohol)-borax as the first network and P(AM-co-NaAA) as the second network. The nanocomposite hydrogels were characterized by FTIR, XRD and TEM analyses. FTIR analysis revealed the successful incorporation of silver particles because of the observation of coordination of Ag + ions with the carboxylate (–COO) group of NaAA component present in the hydrogels. The characteristic presence of face-centered crystalline silver nanoparticles into the hydrogels was observed in X-ray diffractogram. The diameters of such AgNPs were observed to be in the range of 10–40 nm by TEM. These Ag-IDN nanocomposite hydrogels were further characterized for their swelling behavior and swelling kinetics as well as antibacterial property. The incorporation of AgNPs into the polymer network led to decrease of the swelling capacity of the hydrogels. The swelling characteristic constant (K) of the nanocomposite hydrogels was less than that of the virgin IDN hydrogels. Such Ag-IDN nanocomposite hydrogels exhibited antibacterial activity toward gram-positive and gram-negative bacteria. However, among the four nanocomposite hydrogels studied in this investigation, Ag-IDN-2 exhibited the best growth inhibition of Bacillus subtills (Gram + ve) whereas Ag-IDN-3 for Escherichia coli (Gram –ve) microorganisms. Such Ag-IDN nanocomposite hydrogels may find potential biomedical applications.



中文翻译:

高溶胀银纳米复合离子双网络(Ag-IDN)水凝胶的合成及其特性研究

如今,银纳米颗粒 (AgNP) 嵌入的纳米复合水凝胶是非常有吸引力的生物医学应用软材料。在这项研究中,通过在完全溶胀的水凝胶中使用柠檬酸原位还原 AgNO 3,将 AgNPs 结合到离子双网络 (IDN) 水凝胶中。IDN 水凝胶是 pH 响应多功能双网络,由聚乙烯醇-硼砂作为第一个网络和 P(AM-co-NaAA) 作为第二个网络组成。通过FTIR、XRD和TEM分析表征纳米复合水凝胶。FTIR 分析显示银颗粒成功掺入,因为观察到 Ag + 离子与羧酸盐 (-COO -) 水凝胶中存在的一组 NaAA 组分。在 X 射线衍射图中观察到面心结晶银纳米颗粒进入水凝胶的特征存在。通过 TEM 观察到这种 AgNPs 的直径在 10-40 nm 的范围内。这些 Ag-IDN 纳米复合水凝胶的溶胀行为和溶胀动力学以及抗菌性能得到了进一步表征。将 AgNPs 掺入聚合物网络导致水凝胶的溶胀能力降低。纳米复合水凝胶的溶胀特性常数 (K) 小于原始 IDN 水凝胶的溶胀特性常数 (K)。这种Ag-IDN纳米复合水凝胶对革兰氏阳性菌和革兰氏阴性菌表现出抗菌活性。然而,在本研究中研究的四种纳米复合水凝胶中,枯草芽孢杆菌(Gram + ve) 而 Ag-IDN-3 用于大肠杆菌 (Gram –ve )微生物。这种 Ag-IDN 纳米复合水凝胶可能有潜在的生物医学应用。

更新日期:2021-08-02
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