当前位置: X-MOL 学术Aging Male › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Testosterone status is not associated with bladder cancer parameters in adult male patients: results of a prospective controlled study
The Aging Male ( IF 2.6 ) Pub Date : 2021-08-02 , DOI: 10.1080/13685538.2020.1808968
Alper Kafkasli 1 , Ozgur Yazici 2 , Utku Can 1 , Erdinç Dinçer 1 , Oktay Akça 1 , Onder Canguven 3, 4
Affiliation  

Abstract

Purpose

This controlled study assessed whether there was a correlation between serum total testosterone levels and bladder cancer (BCa) in terms of tumor grade and stage as objective measures in adult men.

Materials and method

Our prospectively-designed study included 257 patients who were diagnosed with primary BCa and its surgery between January 2017 and January 2020. Hundred and forty patients who had surgery in the same period with TUR for prostate or endoscopic ureteral stone treatment were included in the study as a control group. All patients in the study and control groups were male. The age range of the patients was between 34 and 90 years old. In order to examine groups, fasting blood glucose, lipid profile, albumin, total testosterone, and vitamin D levels of all patients included in the study.

Results

The relationship between tumor aggression and total testosterone level was investigated with a multinomial logistic regression model, where the control group was accepted as a reference, following adjustment for potential confounding variables, including age and serum albumin levels. Testosterone level was not found to be associated with any of the categories that determine tumor aggressiveness (p > 0.05).

Conclusion

In the present study, there was no correlation between any categories that determine tumor aggressiveness of BCa and total testosterone levels in adult men. It is obvious that our findings should be supported and further investigations are needed.



中文翻译:

成年男性患者的睾酮状态与膀胱癌参数无关:一项前瞻性对照研究的结果

摘要

目的

这项对照研究评估了血清总睾酮水平与膀胱癌 (BCa) 在肿瘤分级和分期方面是否存在相关性,作为成年男性的客观指标。

材料和方法

我们前瞻性设计的研究纳入了 2017 年 1 月至 2020 年 1 月期间被诊断为原发性 BCa 及其手术的 257 名患者。研究中包括同期接受 TUR 手术治疗前列腺或内窥镜输尿管结石的 140 名患者。一个对照组。研究组和对照组的所有患者均为男性。患者的年龄范围在 34 至 90 岁之间。为了检查各组,研究中包括的所有患者的空腹血糖、血脂、白蛋白、总睾酮和维生素 D 水平。

结果

使用多项逻辑回归模型研究肿瘤侵袭性与总睾酮水平之间的关系,其中对照组被接受为参考,并调整了潜在的混杂变量,包括年龄和血清白蛋白水平。未发现睾酮水平与确定肿瘤侵袭性的任何类别相关(p  > 0.05)。

结论

在本研究中,确定 BCa 肿瘤侵袭性的任何类别与成年男性的总睾酮水平之间没有相关性。很明显,我们的发现应该得到支持,需要进一步的调查。

更新日期:2021-08-02
down
wechat
bug