ABSTRACT

Introduction: Breast cancer (BC) is the most significant threat to women’s life. To demonstrate its molecular mechanisms, which results in BC progression, it is crucial to develop approaches to enhance prognosis and survival in BC cases.

Areas covered: In the current study, we aimed to highlight the updated data on the oncogenic and tumor suppressive roles of lncRNAs in the progression of various subtypes of BC by specifically putting importance on the functional characteristics, modulatory agents, therapeutic potential, future perspectives and challenges of lncRNAs in BC. We reviewed recent studies published between 2019 and 2020.

Expert opinion: The latest investigations have demonstrated that the long non-coding RNAs (lncRNAs) participate in different BC molecular subtypes via different molecular mechanisms; however, the exact functional information of the lncRNAs has yet to be elucidated. The studied lncRNAs could be more applicable as therapeutic targets in BC treatment after pre-clinical and clinical studies.

摘要

简介: 乳腺癌 (BC) 是对女性生命的最大威胁。为了证明其导致 BC 进展的分子机制，开发提高 BC 病例预后和存活率的方法至关重要。

涵盖的领域：在目前的研究中，我们旨在通过特别重视功能特征、调节剂、治疗潜力、未来前景和BC 中 lncRNA 的挑战。我们回顾了 2019 年至 2020 年间发表的最新研究。

专家意见：最新研究表明，长链非编码RNA（lncRNA）通过不同的分子机制参与不同的BC分子亚型；然而，lncRNA的确切功能信息尚未阐明。在临床前和临床研究后，所研究的 lncRNA 可能更适合作为 BC 治疗的治疗靶点。