A traditional hallmark of cognitive impairment associated with late-onset Alzheimer´s disease (LOAD) is episodic memory impairment. However, early alterations have been identified in brain regions associated with executive function in asymptomatic, middle-age offspring of patients with LOAD (O-LOAD) compared to those with no family history. We hypothesized that executive function among O-LOAD would correlate with structural and amyloid brain imaging differently from those without a family history of LOAD (control subjects, CS). Executive function, cortical thickness, and in-vivo Aβ deposits were quantified in 30 O-LOAD and 25 CS. Associations were observed among O-LOAD only. Cortical thickness in the left lateral orbitofrontal cortex was positively associated with Design Fluency. The Stroop Color and Word Test, correlated positively with right rostral mid-frontal cortex thickness. Trails Making Test-B was inversely related to left medial orbitofrontal thickness. Tower of London total time was positively associated with β-amyloid deposition in the right precuneus. These results support previous evidence that early executive dysfunction might reflect subtle, early changes in persons at risk of LOAD and suggests that executive function alterations deserve further exploration in the LOAD literature.

与迟发性阿尔茨海默病 (LOAD) 相关的认知障碍的传统标志是情景记忆障碍。然而，与那些没有家族史的患者相比，在患有 LOAD (O-LOAD) 的患者的中年无症状后代中，与执行功能相关的大脑区域的早期改变已经被发现。我们假设 O-LOAD 中的执行功能与结构和淀粉样蛋白脑成像的相关性与那些没有 LOAD 家族史的人（对照受试者，CS）不同。执行功能，皮质厚度，和体内阿β沉积物在 30 O-LOAD 和 25 CS 中定量。仅在 O-LOAD 中观察到关联。左侧眶额皮质的皮质厚度与设计流畅性呈正相关。Stroop 颜色和单词测试与右侧额叶中额皮质厚度呈正相关。Trails Making Test-B 与左内侧眶额厚度呈负相关。伦敦塔总时间与右楔前叶β-淀粉样蛋白沉积呈正相关。这些结果支持先前的证据，即早期执行功能障碍可能反映了处于 LOAD 风险中的人的细微的早期变化，并表明执行功能的改变值得在 LOAD 文献中进一步探讨。