Esophagitis is prevalent in patients with esophageal dysmotility despite acid suppression, likely related to poor esophageal clearance. Esophageal atresia (EA) is a classic model of dysmotility where this observation holds true. In adult non-dysmotility populations, failure of esophagitis to respond to proton pump inhibitors (PPI) has been linked to variants in CYP2C19 that influence the activity of the encoded enzyme. It is unknown if CYP2C19 metabolizer phenotype contributes to PPI-refractory, non-allergic esophagitis in EA.

中文翻译：

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药物基因组学无法解释质子泵抑制剂难治性食管炎儿童食管闭锁

尽管有抑酸作用，但食管运动障碍的患者仍普遍患有食管炎，这可能与食管清除不良有关。食管闭锁 (EA) 是运动障碍的经典模型，这一观察结果成立。在成人非运动障碍人群中，食管炎对质子泵抑制剂 (PPI) 反应失败与影响编码酶活性的CYP2C19变异有关。目前尚不清楚 CYP2C19 代谢表型是否会导致 EA 中 PPI 难治性非过敏性食管炎。